Roles of mitochondrial iron homeostasis in development and progression of heart failure

线粒体铁稳态在心力衰竭发生和进展中的作用

• 批准号: 17K16016
• 负责人: SATO TATSUYA
• 金额: $ 2.58万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K16016/
• 关键词: ミトコンドリア; 鉄代謝; 心不全; 分子心臓学; 鉄

项目成果

mRNA Binding Protein Tristetraprolin is Required for Cardiac Protection Against Iron Deficiency Through Regulating Production of Mitochondrial Electron Transport Chain Components

mRNA 结合蛋白 Tristetraprolin 是通过调节线粒体电子传递链成分的产生来保护心脏免受铁缺乏所必需的

• 发表时间: 2018
• 作者: Sato T;Chang HC;Bayeva M;Shapiro JS;Ramos-Alonso L;Kouzu H;Jiang X;Liu T;Yar S;Sawicki KT;Chen C;Stumpo DJ;Schumacker P;Blackshear PJ;Ben-Sahra I;Puig S;Ardehali H.
• 通讯作者: Ardehali H.

鉄欠乏に対するミトコンドリアの新規適応機構

线粒体对缺铁的新适应机制

• 发表时间: 2018
• 作者: Sato T;Tanno M;Miki T;Yano T;Chang HC;Ardehali H;Miura T.
• 通讯作者: Miura T.

Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts.

• DOI: 10.14814/phy2.13741
• 发表时间: 2018-06
• 期刊: Physiological reports
• 影响因子: 2.5
• 作者: Mizuno M;Kuno A;Yano T;Miki T;Oshima H;Sato T;Nakata K;Kimura Y;Tanno M;Miura T
• 通讯作者: Miura T

Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats

• DOI: 10.1124/jpet.118.253666
• 发表时间: 2019-03-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Oshima, Hiroto;Miki, Takayuki;Miura, Tetsuji
• 通讯作者: Miura, Tetsuji

Infarct size-liming effect of continuous erythropoietin receptor activator in chronic kidney disease is eliminated by use of its excessive dose.

连续性促红细胞生成素受体激活剂在慢性肾病中的梗死面积限制作用可通过使用过量的剂量而消除。

• 发表时间: 2019
• 作者: Sato T;Yano T;Nishizawa K;Kimura Y;Miki T;Tanno M;Kuno A;Hirata M;Kawasaki R;Miura T
• 通讯作者: Miura T