Effects of impaired response to myocardial mitochondrial iron depletion on the development of heart failure

心肌线粒体铁耗竭反应受损对心力衰竭发展的影响

• 批准号: 19K08522
• 负责人: SATO TATSUYA
• 金额: $ 2.75万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K08522/
• 关键词: 鉄代謝; ミトコンドリア; 心筋症; 慢性腎不全; 心筋ミトコンドリア; 鉄欠乏; 心不全; 酸化ストレス

项目成果

Protective effect of chronic treatment with a continuous erythropoietin receptor activator on CKD-induced myocardial intolerance to ischemia/reperfusion injury is lost by use of its excessive dose.

使用连续促红细胞生成素受体激活剂长期治疗对 CKD 诱导的心肌缺血/再灌注损伤不耐受的保护作用会因使用过量而丧失。

• 发表时间: 2019
• 作者: Tatsuya Sato;Toshiyuki Yano;Keitaro Nishizawa;Yukishige Kimura;Takayuki Miki;Masaya Tanno;Atsushi Kuno;Michinori Hirata;Ryohei Kawasaki;Tetsuji Miura.
• 通讯作者: Tetsuji Miura.

Accumulation of free iron, but not protein-bound iron, in mitochondria may contribute to development of doxorubicin-induced cardiomyopathy

线粒体中游离铁（而非蛋白质结合铁）的积累可能导致阿霉素诱导的心肌病的发生

• 发表时间: 2020
• 作者: Tatsuya Sato;Tatsuya Kikuchi;Toshiyuki Yano;Takayuki Miki;Masaya Tanno;Tetsuji Miura
• 通讯作者: Tetsuji Miura

Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload

• DOI: 10.1016/j.yjmcc.2021.01.002
• 发表时间: 2021-02-09
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Igaki, Yusuke;Tanno, Masaya;Miura, Tetsuji
• 通讯作者: Miura, Tetsuji

Increased glucose oxidation is associated with increased ATP demand in rat fetal hearts just after initiation of the heartbeat through increased glycolytic gene expressions and activated mitochondrial respiration capacity.

葡萄糖氧化的增加与心跳开始后大鼠胎儿心脏中 ATP 需求的增加有关，通过增加糖酵解基因表达和激活线粒体呼吸能力。

• 发表时间: 2020
• 作者: Tatsuya Sato;Nobutoshi Ichise;Takeshi Kobayashi;Hiroya Yamazaki;Yoshinori Terashima;Noritsugu Tohse
• 通讯作者: Noritsugu Tohse