PHARMACOKINETICS IN THE PATIENTS WITH METABOLIC SYNDROME AND APPLICATION FOR PHARMACOTHERAPY

代谢综合征患者的药代动力学及其在药物治疗中的应用

• 批准号: 20249036
• 负责人: INUI Ken-ichi
• 金额: $ 32.03万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20249036/
• 关键词: 薬学; 薬剤反応; 薬物トランスポータ; 転写因子; 核内受容体; メトホルミン; メタボリックシンドローム; 小腸; 腎臓; 肝臓

Drug response is likely altered in the patient with metabolic syndrome. The present results indicated that the expression levels of drug transporters were varied, and pharmacokinetics was changed in several diseases. Especially, we clearly revealed that an efflux transporter MATE1 could influence the sensitivities of anti-diabetic drug metformin and anti-cancer drug cisplatin. These outcomes can lead to the optimized pharmacotherapy in metabolic syndrome patients.

代谢综合征患者的药物反应可能发生改变。目前的研究结果表明，药物转运蛋白的表达水平是不同的，药代动力学改变了一些疾病。特别是，我们清楚地表明，外排转运蛋白MATE1可以影响抗糖尿病药物二甲双胍和抗癌药物顺铂的敏感性。这些结果可以导致代谢综合征患者的最佳药物治疗。

项目成果

Time-dependent changes of urinary biomarkers in the lung cancer patients after cisplatin-based chemotherapy

肺癌患者顺铂化疗后尿液生物标志物的时间依赖性变化

• 发表时间: 2010
• 作者: Sato;T.;et al.
• 通讯作者: et al.

PREDOMINANT ROLE OF H^+/ORGANIC CATION ANTIPORTER MATE1/SLC47A1 IN THE RENAL TUBULAR SECRETION OF METFORMIN AND CEPHALEXIN.

H^/有机阳离子反向转运蛋白 MATE1/SLC47A1 在二甲双胍和头孢氨苄肾小管分泌中的主要作用。

• 发表时间: 2010
• 作者: Kohga K;Takehara T;他;Inui K
• 通讯作者: Inui K

Organic cation transporter OCT/SLC22A and H+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents.[Review]

有机阳离子转运蛋白OCT/SLC22A和H+/有机阳离子逆向转运蛋白MATE/SLC47A是铂类药物肾毒性的关键分子。[综述]

• 发表时间: 2011
• 期刊: Biochemical Pharmacology
• 影响因子: 5.8
• 作者: Yonezawa;A.;et al.
• 通讯作者: et al.

Heterozygous variants of multidrug and toxin extrusions(MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients

多药和毒素挤出的杂合变异体（MATE1和MATE2-K）对糖尿病患者二甲双胍的处置影响不大

• DOI: 10.1097/fpc.0b013e328335639f
• 发表时间: 2010
• 期刊: Pharmacogenet. Genomics
• 作者: Toyama K;Yonezawa A;Tsuda M;Masuda S;Yano I;Terada T;Osawa R;Katsura T;Hosokawa M;Fujimoto S;Inagaki N;Inui K
• 通讯作者: Inui K

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

• DOI: 10.1124/mol.109.056242
• 发表时间: 2009-06-01
• 期刊: MOLECULAR PHARMACOLOGY
• 影响因子: 3.6
• 作者: Tsuda, Masahiro;Terada, Tomohiro;Inui, Ken-ichi
• 通讯作者: Inui, Ken-ichi