Comprehensive analysis of neuronal regeneration, inflammation and gene therapy for post-ischemic insult by using experimental stroke models

本研究应用多种实验性脑卒中模型进行基础研究，对缺血损伤后神经元再生、炎症反应和缺血耐受进行了综合分析。由于细胞移植治疗轴突再生的可能性，少量的移植细胞留在损伤处，表现为仅仅归巢，既没有增殖也没有重新连接。亲环素C相关蛋白（Cyclophilin C-associated protein，CyCAP）在脑缺血后的免疫反应中，通过刺激钙调磷酸酶活性，对巨噬细胞的活化起关键作用。缺血耐受现象可能与低氧预适应和血管重构有关。

By applying variety of experimental stroke models for the basic research, we have exerted the comprehensive analysis of neuronal regeneration, inflammation and ischemic tolerance after ischemic insult. For the possibility of axonal regeneration treated by the cell transplantion, the small number of the transplanted cells remain in the lesion, appearing just homing, neither proliferation nor rewiring. In terms of the immunoreactions to ischemic insult of the brain, Cyclophilin C-associated protein(CyCAP), via stimulating calcineurin phosphatase activity, plays a pivotal role for activation of macrophage. The phenomenon of ischemic tolerance may link hypoxic preconditioning with vascular remodeling.