Comprehensive analysis of neuronal regeneration, inflammation and gene therapy for post-ischemic insult by using experimental stroke models

通过应用多种脑卒中实验模型进行基础研究，对缺血性损伤后神经元再生、炎症和缺血耐受进行了综合分析。对于细胞移植治疗轴突再生的可能性，少量移植细胞停留在病变部位，仅表现为归巢，既不增殖也不重新布线。在脑缺血损伤的免疫反应中，嗜环蛋白c相关蛋白（Cyclophilin C-associated protein, CyCAP）通过刺激钙调磷酸酶活性，对巨噬细胞的活化起关键作用。缺血耐受现象可能与缺氧预处理与血管重构有关。

By applying variety of experimental stroke models for the basic research, we have exerted the comprehensive analysis of neuronal regeneration, inflammation and ischemic tolerance after ischemic insult. For the possibility of axonal regeneration treated by the cell transplantion, the small number of the transplanted cells remain in the lesion, appearing just homing, neither proliferation nor rewiring. In terms of the immunoreactions to ischemic insult of the brain, Cyclophilin C-associated protein(CyCAP), via stimulating calcineurin phosphatase activity, plays a pivotal role for activation of macrophage. The phenomenon of ischemic tolerance may link hypoxic preconditioning with vascular remodeling.