Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research
Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research
批准号:
20249066
负责人:
TERAKAWA Naoki
金额:
$30.87万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011
中文摘要
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英文摘要
This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data collected from approximately 2, 000 patients diagnosed as endometriosis. Of these patients, seven patients who have had ovarian cancer derived from endometrioma until 2011, and this research work will be conducted for next 10 years. In the basic molecular experiments, only the epithelial cells derived from ovarian endometrioma and clear cell carcinoma of ovary were captured, and analyzed gene expression profile by using the comprehensive cDNA microarray. We assessed the expression and function of fibroblast growth factor receptor(FGFR)-2 associated with the malignant transformation of endometrioma.
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Apigeninによる子宮内膜症間質細胞の増殖およびPGE2産生の抑制
芹菜素抑制子宫内膜异位基质细胞增殖和 PGE2 产生
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[周防加奈、谷口文紀、原田省寺川直樹, 他]
通讯作者:
他
DOI:
10.1016/j.fertnstert.2007.02.060
发表时间:
2008-02
期刊:
Fertility and sterility
影响因子:
6.7
作者:
[F. Taniguchi;T. Harada;T. Iwabe;Yoko Ohama;Y. Takenaka;N. Terakawa]
通讯作者:
F. Taniguchi;T. Harada;T. Iwabe;Yoko Ohama;Y. Takenaka;N. Terakawa
Possible involvement of survivin in resistance to drug-induced apoptosis of endometriotic stromal cells
生存素可能参与抵抗药物诱导的子宫内膜异位基质细胞凋亡
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Watanabe A, Taniguchi F, Harada T, et al]
通讯作者:
et al
子宮内膜症細胞の増殖におけるシグナル分子TAK1の役割
信号分子TAK1在子宫内膜异位症细胞增殖中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Taniguchi F, Tagashira Y, Suou K, Iwabe T, Harada T, 谷口文紀]
通讯作者:
谷口文紀
DNAマイクロアレイを用いた子宮内膜症細胞における遺伝子解析-子宮内膜症細胞の増殖におけるシグナル分子TAK1の役割-
使用 DNA 微阵列对子宫内膜异位症细胞进行遗传分析 - 信号分子 TAK1 在子宫内膜异位症细胞增殖中的作用 -
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[早川智, 相澤志保子, 早川智・相澤(小峯)志保子, 早川智, Y. Ohama, F. Taniguchi, Y. Ohama, F. Taniguchi, F. Taniguchi, Y. Ohama, N. Miura, T. Shoji, N. Miura, T. Shoji, M.Izawa, M. Ito, M. Mitsunari, M. Izawa, M. Ito, M. Mitsunari, M.Izawa, I. Deura, S. Horie, I. Deura, S. Horie, I.Deura, S.Horie, M. Izawa, Y. Ohata, T. Harada, T. Harada, Y. Tagashira, M. Izawa, Y. Ohata, T. Harada, T. Harada, Y. Tagashira, T. Iwabe, I. Deura, A. Ikeda, T. Iwabe, I. Deura, A. Ikeda, 寺川直樹, 寺川直樹, 谷口文紀, 田頭由紀子, 寺川直樹, M. Izawa, Y. Tagashira, T. Harada, M. Izawa, Y. Tagashira, T. Harada, 渡邉彩子, 大畠順恵, 片桐千恵子, 岩部富夫, 田頭由紀子, 伊澤正郎, 池田綾子, 山浦伊万里, 谷口文紀]
通讯作者:
谷口文紀
共 54 条
Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis
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批准号:17390451
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.88万
-
财政年份:2005
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负责人:TERAKAWA Naoki
-
依托单位:
Role of matrix met alloprot einases and cytokines in the development of endometriosis
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批准号:14370534
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.71万
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财政年份:2002
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负责人:TERAKAWA Naoki
-
依托单位:
Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis
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批准号:11470350
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$4.22万
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财政年份:1999
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负责人:TERAKAWA Naoki
-
依托单位:
Interleukin-8 is a possible angiogenic factor in endometrial cancer
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批准号:08457442
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.65万
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财政年份:1996
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负责人:TERAKAWA Naoki
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依托单位:
Effects of medroxyprogesterone acetate and synthetic analogue of fumagillin on endometrial cancer
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批准号:06454474
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1994
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负责人:TERAKAWA Naoki
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依托单位:
A combination therapy of danazol and GnRH agonist for endometriosis
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批准号:04454420
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.82万
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财政年份:1992
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负责人:TERAKAWA Naoki
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依托单位:
Studies on Endocrine Therapy for Endometriosis
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批准号:01480393
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.62万
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财政年份:1989
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负责人:TERAKAWA Naoki
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依托单位:
The role of connective tissue elements in the hormonally induced functional defferentiation of mouse mammary gland in culture
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批准号:61570794
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.6万
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财政年份:1986
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负责人:TERAKAWA Naoki
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依托单位:
海外基金