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Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis

Effects of cytokines on the pathogenesis of endometriosis and infertility associated with endometriosis
细胞因子对子宫内膜异位症发病机制及子宫内膜异位症相关不孕症的影响
批准号:
11470350
负责人:
TERAKAWA Naoki
金额:
$4.22万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B).
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 2000

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中文摘要
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英文摘要
Endometriosis, which occurs in 10% of reproductive aged women, is characterized by the presence and growth of endometrial-like tissue outside the uterus. The pathogenesis of endometriosis and its link to infertility is controversial. Peritoneal fluid in women with endometriosis contains an increased number of activated macrophages that secrete a variety of cytokines, including interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNFα). The purpose of this study is to investigate whether IL-6, IL-8 and TNFα are related to progress and infertility of this disease.Peritoneal fluid levels of IL-6, IL-8 and TNFα were significantly higher in patients with endometriosis compared with patients without endometriosis. The concentrations of these cytokines in patients with active endometriosis increased as the size and number of active lesions increased. Expressions of transcripts of IL-6 receptor, glycoprotein 130, IL-8 receptor and TNFα receptor were observed in both endometrial and endometrio … More tic stromal cells.Tumor necrosis factor-α increased the expression of IL-6 messenger RNA and protein in endometriotic cells in a dose-dependent manner. The addition of IL-6 inhibited the development of mouse 1-cell embryo to blastocyst in vitro. The percentage of motile spermatoza decreased by the addition of both IL-6 and soluble IL-6 receptor. These results suggested that IL-6 may relate to the infertility associated with endometriosis.Interleukin-6 had no effect on the growth of stromal cells in endometrial tissue from the proliferative phase. In contrast, the addition of IL-6 induced significant inhibition of stromal cells in tissue from the secretary phase. On the other hand, stromal cells of endometriotic tissues were resistant to IL-6, showing no inhibitory response. Interleukin-8 significantly increased the number of cells and DNA synthesis in the endometriotic stromal cells in a dose-dependent manner. Tumor necrosis factor-α induced the gene and protein expression of IL-8 in endometriotic stromal cells in a dose-dependent fashion. The addition of TNF α promoted the proliferation of the endometriotic stromal cells, and the stimulatory effects of TNF α were abolished by the adding anti-IL-8 antibody. These cytokines may associate with the progression of the disease.In conclusion, IL-6, IL-8 and TNF α may contribute to the pathogenesis of endometriosis and infertility associated with endometriosis. Less
期刊论文(22)
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会议论文
H.Yoshioka, T.Harada, T.Iwabe, Y.Nagano, F.Taniguchi, M.Tanikawa, N.Terakawa: "Menstrual cycle-specific inhibition of the proliferation of endometrial stromal cells by interleukin 6 and its soluble receptor."Am J Obstet Gynecol. 180(5). 1088-1094 (1999)
H.Yoshioka、T.Harada、T.Iwabe、Y.Nagano、F.Taniguchi、M.Tanikawa、N.Terakawa:“白细胞介素 6 及其可溶性受体对月经周期特异性抑制子宫内膜基质细胞的增殖。”
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发表时间:
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通讯作者:
寺川直樹: "子宮内膜症とサイトカイン"日本産科婦人科学会雑誌. 52 8. 1202-1207 (2000)
Naoki Terakawa:“子宫内膜异位症和细胞因子”日本妇产科学会杂志 52 8. 1202-1207 (2000)。
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通讯作者:
T.Iwabe, T.Harada, T.Tsudo, Y.Nagano, S.Yoshida, M.Tanikawa, N.Terakawa: "Tumor necrosis factor-α promotes proliferation of endometriotic stromal cells by inducing interleukin-8 gene and protein expression."J Clin Endocrinol Metab. 85(2). 824-829 (2000)
T.Iwabe、T.Harada、T.Tsudo、Y.Nagano、S.Yoshida、M.Tanikawa、N.Terakawa:“肿瘤坏死因子-α 通过诱导白细胞介素 8 基因和蛋白表达来促进子宫内膜异位基质细胞的增殖。 “J Clin Endocrinol Metab. 85(2).824-829 (2000)
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发表时间:
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作者: []
通讯作者:
H.Yoshioka: "Menstrual cycle-specific inhibition of the proliferation of endometrial stromal cells by interleukin 6 and its solube receptor"Am.J.Obstet.Ginecol.. 188・5. 1088-1094 (1999)
H. Yoshioka:“白细胞介素 6 及其溶解受体对子宫内膜基质细胞增殖的月经周期特异性抑制”Am. J. Ginecol.. 188・5 (1999)。
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通讯作者:
9
    Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research
    • 批准号:
      20249066
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $30.87万
    • 财政年份:
      2008
    • 负责人:
      TERAKAWA Naoki
    • 依托单位:
    Exploring the mechanism of cell proliferation and the novel molecular target therapy of endometriosis
    • 批准号:
      17390451
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.88万
    • 财政年份:
      2005
    • 负责人:
      TERAKAWA Naoki
    • 依托单位:
    Role of matrix met alloprot einases and cytokines in the development of endometriosis
    • 批准号:
      14370534
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.71万
    • 财政年份:
      2002
    • 负责人:
      TERAKAWA Naoki
    • 依托单位:
    Interleukin-8 is a possible angiogenic factor in endometrial cancer
    • 批准号:
      08457442
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.65万
    • 财政年份:
      1996
    • 负责人:
      TERAKAWA Naoki
    • 依托单位:
    海外基金