Bioimaging of mitochondrial dynamics and generation of model mice

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To disclose the relationships between mitochondrial-dynamics' malfunctions and diseases, we tried to develop a detection systems of the malfunctions by bioimaging and to generated disease model mice caused by the malfunction. The detection systems based on bioimaging have been successfully developed by generating many lines of transgenic mice with mitochondrially expressed fluorescent proteins such as EGFP, DsRed, etc. The generation of disease model mice caused by malfunction of mitochondrial dynamics is still in progress.