Super-resolution sensing using nanolasers

我们研制了一种基于光子晶体纳米激光的高灵敏度生物传感器。在针对具有低附着力的BSA蛋白质的测试实验中，实现了255fM的非常低的检测限，表明了优异的灵敏度。在针对SA蛋白的更实际的实验中，在没有污染物的情况下检测到60 μ M的超低浓度，并且即使在1万亿更高浓度的BSA作为污染物的情况下也检测到<1 μ M。这些结果满足了医学诊断对人体血液中低浓度生物标志物检测的要求。

We developed high-sensitivity bio-sensor based on photonic crystal nanolasers with a nano-slot structure. In a test experiment against BSA protein with a low attachment force, a very low detection limit of 255 fM was achieved, suggesting an excellent sensitivity. In a more practical experiment against SA protein, an ultralow concentration of 60 zM was detected without contaminants and<1 aM even with 1 trillion higher concentration BSA as contaminants. These results satisfy the requirements from medical diagnoses for detecting low-concentration bio-markers in human blood.