Innovative research on molecular systems of immune cells using combination of single molecule imaging and numerical modeling
Innovative research on molecular systems of immune cells using combination of single molecule imaging and numerical modeling
批准号:
21247019
负责人:
TOKUNAGA Makio
金额:
$19.22万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Single molecule imaging coupled with the ability to simultaneously visualize several different proteins in cells has enabled the quantification of molecular dynamics, interactions, and kinetics. Based on these three-dimensional and temporal parameters, we examine numerical modeling and computer simulations of cell functions. Using the combination of single molecule quantification and "in silico" modeling, we opened up new frontiers for understanding cells as molecular systems.
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Stochastic and dynamic pathways detected by quasi-static mechanical unzipping of single-base pair of DNA and MD simulations.
通过 DNA 单碱基对的准静态机械解压缩和 MD 模拟检测随机和动态路径。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Fukagawa A., Hiroshima M., Tokunaga M.]
通讯作者:
Tokunaga M.
細胞内蛍光1分子イメージングと定量解析
细胞内荧光单分子成像与定量分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[川住愛子, 中村哲也, 岩井なおみ, 八代健太, 西條幸男, Jose Belo, 白鳥秀卓, 濱 田 博 司, 徳永万喜洋,十川久美子]
通讯作者:
徳永万喜洋,十川久美子
シグナル伝達活性化におけるT細胞受容体分子会合の1分子解析
信号转导激活过程中 T 细胞受体分子关联的单分子分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ono M., M. Kataoka, M. Yokoyama, O. Ifuku, M. Ohta, S. Arai, H. Kamada, K. Sage-Ono, 徳永万喜洋,十川久美子]
通讯作者:
徳永万喜洋,十川久美子
RNA granule protein RNG140 is a paralog of RNG105 and localized to distinct RNA granules in the brain of adult vertebrates
RNA 颗粒蛋白 RNG140 是 RNG105 的旁系同源物,定位于成年脊椎动物大脑中的不同 RNA 颗粒
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shiina N, Tokunaga M]
通讯作者:
Tokunaga M
Single molecule imaging and quantitative analysis of activation of T cell signaling with stimulatory lipid bilayers
刺激性脂质双层激活 T 细胞信号传导的单分子成像和定量分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ito Y, Sakata-Sogawa K, Tokunaga M]
通讯作者:
Tokunaga M
共 56 条
Quantification of molecular dynamics, numbers and interactions of multi-kind molecules by single molecule imaging in cells
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批准号:18370065
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.57万
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财政年份:2006
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负责人:TOKUNAGA Makio
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依托单位:
Single molecule research of molecular interactions using scanning probe microscopy
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批准号:10480185
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:1998
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负责人:TOKUNAGA Makio
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依托单位:
海外基金