Spacial regulation of cells during organogenesis

在发育过程中，细胞分化和组织形成需要在合适的时间和空间进行。这项研究的目的是了解细胞和组织如何在发育中的胚胎中正确分布。我们特别关注神经嵴细胞，这些细胞在从神经管迁移后进行动态迁移。我们发现神经嵴细胞与非神经嵴细胞密切相互作用，并且这种相互作用涉及复杂的分子级联反应。本研究揭示的细胞和分子机制有望为其他形态发生过程所共享。

During development, cell differentiation and tissue formation need to proceed at the right time and right space. The aim of this research is to understand how cells and tissues are correctly distributed in the developing embryo. We address such questions with a particular focus on neural crest cells, which undergo dynamic migration after emigrating from the neural tube. We found that neural crest cells intimately interact with non-neural crest cells, and also that complex molecular cascades are involved in such interactions. The cellular and molecular mechanisms revealed in this study are expected to be shared by other morphogenetic processes.