Fine Organic Synthesis based on Catalytic Regioselective Functionalization

通过有机催化的区域选择性酰化反应，实现了天然糖苷tellimagrandin II的一步全合成。建立了天然强心苷毛花苷C的一步区域选择性功能化方法。四取代烯二醇的几何选择性酰化反应和σ-对称长链烷二醇的高对映选择性不对称去对称化反应也得到了发展。

Short-step total synthesis of natural glycoside, tellimagrandin II, was achieved via organocatalytic regioselective acylation. A method for one-step regioselective functionalization of natural cardiac glycoside, lanatoside C, was developed. Geometry-selective acylation of tetrasubstituted alkendiols and highly enantioselective asymmetric desymmterization of σ-symmetric long-chain alkane diols were also developed by organocatalysis.