Fine Organic Synthesis based on Catalytic Regioselective Functionalization

通过有机催化的区域选择性酰化反应，实现了天然糖苷的短步全合成。研究了天然心脏糖苷lanat苷C的一步区域选择性功能化方法。通过有机催化反应，研究了四取代烯烃的几何选择性酰化反应和σ对称长链烷烃的高度对映选择性不对称脱对称反应。

Short-step total synthesis of natural glycoside, tellimagrandin II, was achieved via organocatalytic regioselective acylation. A method for one-step regioselective functionalization of natural cardiac glycoside, lanatoside C, was developed. Geometry-selective acylation of tetrasubstituted alkendiols and highly enantioselective asymmetric desymmterization of σ-symmetric long-chain alkane diols were also developed by organocatalysis.