The immunopathological study on leukocyte adhesion molecule DNAM-1 (CD226)

癌症、自身免疫性疾病和传染性疾病的免疫反应的分子机制尚不清楚。阐明分子机制是克服这些顽固性疾病的基本要求。我们之前发现白细胞激活受体DNAM-1在NK细胞、T细胞和巨噬细胞及其配体上表达。在本研究中，我们阐明了DNAM-1在疾病发病机制中的作用，为这些疾病的分子靶向治疗奠定了基础。

The molecular mechanisms underlying immune responses to cancer, autoimmune diseases, and infectious diseases have been unclear. Elucidation of the molecular mechanisms is essentially required to overcome these intractable diseases. We previously identified leukocyte activating receptor DNAM-1 that is expressed on NK cells, T cell and macrophages ant its ligands. In this study, we clarify the role of DNAM-1 in the pathogenesis of diseases and develop the basis of molecular targeting therapy to these diseases.