Deciphering the role of protrudin regulating neuronal vesicular transport
Deciphering the role of protrudin regulating neuronal vesicular transport
批准号:
22240038
负责人:
NAKAYAMA Keiichi
金额:
$31.95万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We investigated the structure-function relationship of protrudin that regulates intracellular vesicle transport in neurons. Protrudin interacts with Rab11 through the RBD11 domain, with VAP and KIF5 through the FFAT motif, and sulfatide and PI(5)P through the atypical FYVE domain. We also created mice deficient in protrudin and found that anatomical and physiological alterations in the mutant mice, suggesting that protrudin contributes to vesicular trafficking in neuronal cells
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Next-generation proteomics uncovers the secret of cancer
下一代蛋白质组学揭示了癌症的秘密
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Nakayama, K. I]
通讯作者:
K. I
プロテオミクスが拓く細胞周期研究
蛋白质组学开创的细胞周期研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松本雅記, 中山敬一]
通讯作者:
中山敬一
創薬・タンパク質研究のためのプロテオミクス解析
用于药物发现和蛋白质研究的蛋白质组学分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松本雅記, 中山敬一]
通讯作者:
中山敬一
プロテオミクスが拓く細胞周期研究. 細胞周期フロンティア
细胞周期研究由蛋白质组学开创。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松本雅記, 中山敬一]
通讯作者:
中山敬一
DOI:
10.1038/nature09732
发表时间:
2011-03-03
期刊:
NATURE
影响因子:
64.8
作者:
[Inuzuka, Hiroyuki, Shaik, Shavali, Onoyama, Ichiro, Gao, Daming, Tseng, Alan, Maser, Richard S., Zhai, Bo, Wan, Lixin, Gutierrez, Alejandro, Lau, Alan W., Xiao, Yonghong, Christie, Amanda L., Aster, Jon, Settleman, Jeffrey, Gygi, Steven P., Kung, Andrew L., Look, Thomas, Nakayama, Keiichi I., DePinho, Ronald A., Wei, Wenyi]
通讯作者:
Wei, Wenyi
共 34 条
Elucidation of Warburg effect in cancer with the next-generation proteomics
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批准号:26640080
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2014
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负责人:NAKAYAMA Keiichi
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依托单位:
Deciphering the mechanisms underlying cancer development induced by deregulation of proteolysis
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批准号:17013067
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$30.46万
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财政年份:2005
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负责人:NAKAYAMA Keiichi
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依托单位:
Isolation and characterization of protrudin, a master regulator of neurite formation
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批准号:17107004
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$71.47万
-
财政年份:2005
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负责人:NAKAYAMA Keiichi
-
依托单位:
Analysis of the PKC-δ Signaling Pathway by Proteomics with Embryonic and Genetic Engeneering
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批准号:15370060
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.86万
-
财政年份:2003
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负责人:NAKAYAMA Keiichi
-
依托单位:
New cancer therapy by degradation of specific proteins
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批准号:13557019
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.02万
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财政年份:2001
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负责人:NAKAYAMA Keiichi
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依托单位:
New clearance system of abnormal protein in Polyglutammine disease
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批准号:13480258
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.66万
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财政年份:2001
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负责人:NAKAYAMA Keiichi
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依托单位:
Investigation into the molecular mechanisms underlying proteolysis of CDK inhibitor p27
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批准号:12213097
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$35.97万
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财政年份:2000
-
负责人:NAKAYAMA Keiichi
-
依托单位:
Studies on the construction of a system of water management in the greening process of land.
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批准号:07456118
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.01万
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财政年份:1995
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负责人:NAKAYAMA Keiichi
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依托单位:
Studies on the development of model to estimate the soil moisture with AMeDAS data
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批准号:63560248
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1988
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负责人:NAKAYAMA Keiichi
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依托单位:
海外基金