Development of advanced bioimaging technology based on integration of optics and ultrasound by spatio-temporal modulation

我们研究了光学和超声技术相结合的先进生物成像方法的发展，该方法具有无创、易于使用和实时性等共同优点。基于光学与超声的相互作用，即光脉冲编码激发对超声的调制和超声调制光学对光散射的控制，我们开发了具有高信噪比、时间分辨率和大测量深度的先进光声成像的基础技术。仿真和仿真实验验证了所提方法的有效性。

We investigated development of the advanced bioimaging method by integration of optics and ultrasound technologies which have common merits such as non-invasive, easy-to-use and real-time. Based onthe interaction between optics and ultrasound, i.e., the modulation of ultrasound by coded excitation of optical pulse, and the control of optical scattering by ultrasound-modulated optics, we developed fundamental technologies for the advanced photo-acoustic imaging with high SNR, temporal resolution and large measurable depth. The performance of proposed methods was validated by simulation and phantom experiments.