Development of Endoscopic Ultrasound System for Tissue Elasticity Imaging

组织弹性成像内窥镜超声系统的开发

• 批准号: 16300169
• 负责人: SHIINA Tsuyoshi
• 金额: $ 7.3万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300169/
• 关键词: ultrasound measurement; tissue elasticity imaging; cancer diagnosis; non-invasive biological measurement; endoscopic method; medical image diagnosis; image-guided therapy; improvement of quality of life

Ultrasonic tissue elasticity imaging can provide us novel diagnostic information based on tissue hardness and consequently it is expected to detect tumor with high contrast and also discriminate benign and malignant disease. We recently developed commercial-based equipment for real-time tissue elasticity imaging based on the combined autocorrelation method which we have previously proposed to attain the high precision of diagnosis with simple operation as well as ordinary ultrasonic examination. On the other hand, there remains a problem that conventional elasticity image is not quantitative since it depends on the compression level. In addition, endoscopic measurement is expected to be useful for improving precision of diagnosis based on tissue characterization as well as percutaneous approaches.From this point of view, we aim to develop the endoscopic ultrasound systems for tissue elasticity imaging by quantification of conventional strain images and expansion of fields for clinical … More application.(1) Active compression type of tissue elasticity imagingBy compression of tissues, strain is induced within tissue as well as palpation. As this type, the system for prostate examination by using transrectal probe was investigated. The balloon which was inflated by water was developed for uniform distribution of stress and independence of operators' skill2) Passive compression type of tissue elasticity imagingDeformation of tissues is induced by cardiac motion or blood pressure in this type. The system for evaluation of aortic plaque by transesophageal type of probe was developed. Ultrasonic endoscope was used for reconstruct strain images of pancreas disease.3) Quantitative measurement of tissue elasticityTo elucidate the relation of tissue elasticity and pathological meaning, phantom and tissue specimen are measured by mechanical compression-tester.By way of these investigations, it was attained to develop the basic technology for the endoscopic ultrasound systems for tissue elasticity imaging and give direction to development of practical system Less

超声组织弹性成像能够根据组织的硬度提供新的诊断信息，因此有望在高对比度下检测肿瘤并区分良恶性疾病。我们最近开发的商业为基础的设备，实时组织弹性成像的基础上，我们以前提出的组合自相关方法，以达到高精度的诊断与简单的操作，以及普通的超声检查。另一方面，仍然存在的问题是，传统的弹性图像是不定量的，因为它取决于压缩水平。此外，内窥镜测量有望提高基于组织定征和经皮方法的诊断精度，从这个角度来看，我们的目标是通过量化传统应变图像和扩大临床应用领域，开发用于组织弹性成像的内窥镜超声系统。 ...更多信息 应用程序. (1)主动压缩型组织弹性成像通过压缩组织，在组织内以及触诊中引起应变。作为这种类型，研究了通过使用经直肠探头进行前列腺检查的系统。2）被动压缩型组织弹性成像这种类型的组织变形是由心脏运动或血压引起的。研制了经食管型探头评价主动脉斑块的系统。组织弹性的定量测量为了阐明组织弹性与病理学意义的关系，用机械式压缩试验机对体模和组织标本进行了测量，通过这些研究，我们发现，组织弹性与病理学意义之间存在着一定的关系，而组织弹性与病理学意义之间存在着一定的关系。为超声内窥镜组织弹性成像系统的研制奠定了基础，为实用化的超声内窥镜组织弹性成像系统的研制提供了方向。系统不太

项目成果

Two-Dimensional Elastic Modulus Distribution Reconstruction Based on A Modified Three-Dimensional Finite-Element Model

基于修正三维有限元模型的二维弹性模量分布重构

• 发表时间: 2004
• 期刊: Proc. of the Third International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity
• 作者: 真田茂;宮地利明;田中利恵;他;椎名 毅;Tsuyoshi Shiina;Makoto Yamakawa
• 通讯作者: Makoto Yamakawa

Recent Progress of Ultrasound Elasticity Imaging Technology

超声弹性成像技术最新进展

• 发表时间: 2004
• 期刊: Proc. of Seventh Congress of the Asian Federation of Societies for Ultrasound in Medicine and Biology
• 作者: 真田茂;宮地利明;田中利恵;他;椎名 毅;Tsuyoshi Shiina
• 通讯作者: Tsuyoshi Shiina

Assessment of Vulnerable Coronary Plaque by Intravascular Elasticity Imaging

通过血管内弹性成像评估易损冠状动脉斑块

• 发表时间: 2004
• 期刊: Proc. of 2004 IEEE Ultrasonics Symposium
• 作者: 真田茂;宮地利明;田中利恵;他;椎名 毅;Tsuyoshi Shiina;Makoto Yamakawa;Tsuyoshi Shiina
• 通讯作者: Tsuyoshi Shiina