Evaluation of the Effects of Rehabilitation Based on SerumProteome and Free Amino Acid Levels

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With a view to the establishment of an index marker applicable to patients undergoing rehabilitation, based on biogenic factors, this study aimed to develop a method to evaluate the effects of such approaches, based on serum free amino acid levels. Serum collected from post-acute rehabilitation ward patients was analyzed using UPLC-MS. On single regression analysis of rehabilitation items and changes in amino acid levels, a positive correlation was observed between the lengths of time from the onset to discharge and hospital stay and L-arginine levels, and between FIM gain and L-serine and L-arginine levels, suggesting that changes in serum free amino acidlevels during rehabilitation may depend on the levels of exercise and daily activities.