Intercellular signaling network for the remodeling of skeletal muscle tissue in response to various extracellular stimuli -Application for sports sciences-

本研究旨在探讨不同细胞外刺激下骨骼肌组织重构的细胞内信号网络。研究不同细胞外刺激下骨骼肌组织和培养的肌细胞中旁分泌的骨骼肌特异性分子和骨骼肌膜特异性蛋白的蛋白和mRNA表达水平。有证据表明，骨骼肌源性分子和肌膜特异性蛋白在骨骼肌细胞和骨骼肌组织中的其他细胞之间起着细胞间通讯的作用，调节骨骼肌的大小和功能。

The purpose of this study was to investigate the intracellular signaling networks for the remodeling of skeletal muscle tissue in response to various extracellular stimuli. Protein and mRNA expression levels of skeletal muscle-specific molecules, which paracrine to various cells, and skeletal muscle membrane-specific proteins were evaluated in skeletal muscle tissue as well as cultured muscle cells following various extracellular stimuli. Evidences suggest that skeletal muscle-derived molecules and the muscle membrane-specific proteins function as intercellular communicators between skeletal muscle cells and other cells in skeletal muscle tissue to regulate the size and the function of skeletal muscle.