Development of a Mass Spectrometer based on Wavelength-Tunable Femtosecond Laser Source and Its Application to Scientific Instrumentation

利用双色飞秒激光脉冲与氢气的相互作用，在185~600 nm的宽波长范围内产生了185~600 nm的宽带超短激光发射。我们研究了质谱仪进样的新方案，使灵敏度提高了两倍。200 nm的深紫外光脉冲使我们能够将具有非共轭双键的化合物的检测灵敏度提高两到100倍。实现了三磷酸腺苷分子离子的高产率生成和血液中三磷酸腺苷生成反应路径的研究。对一个含有PCDF、PCDD和PCB32种物质的样品和一个含有PAH和NPAH的PM2.5样品进行了分析。所研制的多色超短紫外激光光源已应用于炸药化合物的分析，证明了采用该光源的质谱计的有效性。

By the interaction between two-color femtosecond laser pulses and hydrogen gas, broadband ultrashort laser emissions from 185 nm to 600 nm have been generated in a broad wavelength range from 185 nm to 600 nm. We have investigated novel schemes of sample injection for mass spectrometer, which resulted in a two times higher sensitivity. A deep-ultraviolet laser pulse at 200 nm has enabled us to increase the detection sensitivity by two to 100 times for compounds with an unconjugated double bond. The generation of the molecular ion of TATP with a high yield and the investigation of the reaction path for the production of TATP in blood have been realized. A sample containing 32 species such as PCDF, PCDD, and PCB, and a sample of PM2.5 containing PAH and NPAH have been analyzed. The developed multicolor ultrashort ultraviolet laser source has been applied for the analysis of explosive compounds to demonstrate the usefulness of the mass spectrometer employing the developed laser source.