Effect of the genetic factors to the physiological polytypisms of modern Japanese

本研究旨在揭示人类生理多态性与mtDNA多态性之间的关系，该多态性被认为与人类移民过程中的冷适应和人类代谢性疾病有关。本研究主要研究低温暴露和低气压-低氧暴露时的生理反应。在10摄氏度和16摄氏度的低温环境中，单倍型D受试者在直肠温度和摄氧量方面表现出更高的耐寒性。在4000m低压-缺氧暴露条件下，单倍型D受试者的SPO2高于其他类型。这些结果提示mtDNA多态性可能影响人类的生理反应，并解释了现代日本人生理多型的部分原因。

This research aimed to reveal the relationship between human physiological polytypisms and mtDNA polymorphism which was suggested to relate cold adaptation during human immigration and human metabolic diseases. Physiological responses during cold exposure and hypobaric - hypoxia exposure were mainly examined in this study. In cold exposure during 10 degrees Celsius and 16 degrees Celsius, haplotype D subjects indicated higher cold tolerance in rectal temperature and oxygen intake. In hypobaric - hypoxia exposure at 4000m, haplotype D subjects had higher SPO2 compared with other type. These results suggested that mtDNA polymorphism might affect human physiological responses and explain a part of physiological polytypisms in modern Japanese.