Nachwuchsakademie ‚Alterungsprozesse in der Reproduktion - Folgen für Fertilität und Gesundheit‘

初级学院“生殖衰老过程 - 对生育和健康的影响”。

• 批准号: 508421992
• 负责人: Professor Dr. Jörg Gromoll
• 金额: --
• 依托单位: Abteilung für Klinische und Operative Andrologie
• 依托单位国家: 德国
• 项目类别: Workshops for Early Career Investigators
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/508421992?language=en
• 关键词: Nachwuchsakademie; Alterungsprozesse; der; Reproduktion; Folgen

Reproduction is a highly complex process of coordinated cellular and endocrine processes exceeding the birth of a child. In addition to a decrease in fertility in men and women, with increasing age also gonadand germ cell-specific aging processes lead to genetic, epigenetic and endocrine changes These not only represent a risk factor for sub-/infertility, but also for progeny health and those of the following generations. The molecular mechanisms that regulate reproductive aging in both sexes are still only partially understood and represent a scientifically challenging topic of research in reproductive medicine of high social relevance considering the rapidly increasing age of parents at birth of the first child. Despite such emerging research questions, the number of university departments for reproductive research in Germany is declining. Besides leading to a lack in research activities, reliable knowledge gain and therapeutic options, Germany also loses connection to the competitive international research level. The junior academy ‘Ageing in Reproduction- impact on fertility and health’ therefore intends to guide young clinicians and scientists towards independent research projects. Participants will receive a training program and support from experienced scientists (mentors) which allow them to submit well-designed pilot applications for research projects and after successful completion of this work the continuation of the scientific work by means of a full DFG-application. We hope that the complex topic of aging processes in reproduction will be accompanied by excellent research and that reproductive research as a whole will be sustainably promoted in Germany.

生殖是一个高度复杂的过程，协调细胞和内分泌的过程超过了一个孩子的出生。除了男性和女性的生育能力下降外，随着年龄的增长，性腺和生殖细胞特异性衰老过程还会导致遗传、表观遗传和内分泌变化，这些变化不仅是亚/不孕症的危险因素，而且还会影响后代和后代的健康。调节两性生殖衰老的分子机制仍然只是部分被理解，并且考虑到父母在第一个孩子出生时的年龄迅速增加，这代表了生殖医学研究中具有高度社会相关性的科学挑战性课题。尽管出现了这样的研究问题，德国从事生殖研究的大学院系的数量却在减少。除了导致缺乏研究活动、可靠的知识获取和治疗选择外，德国还失去了与具有竞争力的国际研究水平的联系。因此，初级学院“生殖中的老龄化——对生育和健康的影响”打算指导年轻的临床医生和科学家进行独立的研究项目。参与者将接受培训计划和经验丰富的科学家（导师）的支持，使他们能够为研究项目提交精心设计的试点申请，并在成功完成这项工作后，通过完整的dfg申请继续科学工作。我们希望，生殖衰老过程这一复杂的课题将伴随着优秀的研究，生殖研究作为一个整体将在德国得到可持续的促进。