Pheromonal control of the hypothalamo-limbic function
下丘脑边缘系统功能的信息素控制
基本信息
- 批准号:15GS0306
- 负责人:
- 金额:$ 359.92万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Creative Scientific Research
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Primer pheromones profoundly influence the brain function and thereby induce various physiological as well as behavoral responses in mammals. Although such phenomena have long been documented, little is known about mammalian primer pheromones. The present study was conducted in order to draw a comprehensive picture of chemical communication via pheromones in mammalian species by focusing on two representative pheromone models, namely the "male effect" pheromone in ruminants and "alarm" pheromone in rodents. We investigated mechanisms of production, perception, neural pathway of these pheromones, and also tried to isolate and identify responsible molecules as pheromone candidates.The "male effect" is a pheromone-induced gonadal activation, which is particularly well known in sheep and goats. The hypothalamic GnRH pulse generator is the target of this pheromone action. We have revealed that the pheromone is perceived by V1R receptors located at both the vomeronasal and olfactory epitheli … More um. Pheromone information is then transmitted via amygdala to the arcuate nucleus of the hypothalamus and stimulates the kisspeptin neuron, which is found to play a key role in generating the pulsatility of GnRH neurosecretion. During the term of this research project we could isolate and identify 16 candidate pheromone substances, of which mixture shows "male effect" pheromone like activity.The "alarm" pheromone is, on the other hand, an olfactory signal, which is emitted from stressed animal for dissemination of potential dangers to family or group members. We have cralified that the pheromone is a water soluble volatile substance released from the peri-anal gland of the donor animal and it is perceived by the vomeronasal organ of the recipient, of which anxiety level is elevated resulting in the increase of risk-assessment as well as defensive behaviors and exacerbation of accompanying autonomic responses. By establishing a bioassay system for the alarm pheromone with measurement of the acoustic startle response we could isolate a candidate pheromone substance, which is currently under investigation for its chemical structure. Less
引子信息素深刻地影响着哺乳动物的大脑功能,从而诱导哺乳动物的各种生理和行为反应。虽然这种现象早已被记录在案,但对哺乳动物的引子信息素知之甚少。本研究旨在通过研究两种具有代表性的信息素模型,即反刍动物的“雄性效应”信息素和啮齿类动物的“报警”信息素,来全面描述哺乳动物物种中通过信息素进行化学交流的情况。我们研究了这些信息素的产生、感知和神经途径的机制,并试图分离和鉴定负责的分子作为信息素候选者。“雄性效应”是信息素诱导的性腺激活,这在绵羊和山羊中尤为常见。下丘脑GnRH脉冲发生器是这种信息素作用的目标。我们已经揭示了信息素是由位于犁鼻和嗅觉上皮…的V1R受体感知的。更多的嗯。信息素信息随后通过杏仁核传递到下丘脑的弓状核,并刺激Kispeptin神经元,后者被发现在产生GnRH神经分泌的脉动性中起关键作用。在本研究项目期间,我们可以分离和鉴定16种候选信息素物质,其中的混合物具有类似雄性效应的信息素活性。另一方面,警报信息素是一种嗅觉信号,从应激动物发出的信号,将潜在的危险传播给家庭或群体成员。我们已经证实,信息素是一种从供体动物肛周腺体释放出来的水溶性挥发性物质,它被受体的犁鼻器感知,焦虑水平上升,导致风险评估以及防御行为的增加和伴随的自主神经反应的加剧。通过建立警报信息素的生物检测系统,结合声学惊吓反应的测量,我们可以分离出一种候选信息素物质,目前正在对其化学结构进行研究。较少
项目成果
期刊论文数量(368)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neuroendocrine control of reproductive function in ruminants
反刍动物生殖功能的神经内分泌控制
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Okamura H.;Ohkura S.
- 通讯作者:Ohkura S.
Distribution of Notchl-expressing cells and proliferating cells in mouse vomeronasal organ
小鼠犁鼻器中Notch1表达细胞和增殖细胞的分布
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Wakabayashi Y.;Ichikawa M.
- 通讯作者:Ichikawa M.
Morphological evidence for two types of Mammalian vomeronasal system.
- DOI:10.1093/chemse/bjh032
- 发表时间:2004-05
- 期刊:
- 影响因子:3.5
- 作者:S. Takigami;Y. Mori;Y. Tanioka;M. Ichikawa
- 通讯作者:S. Takigami;Y. Mori;Y. Tanioka;M. Ichikawa
Scent-marking and sexual activity may reflect social hierarchy among group-living male Mongolian gerbils (Meriones unguiculatus)
气味标记和性活动可能反映了群体生活的雄性蒙古沙鼠(Meriones unguiculatus)的社会等级制度
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Shimozuru M.;Kikusui T.;Takeuchi Y.;Mori Y.
- 通讯作者:Mori Y.
Increase in the number of tyrosine hydroxylase-containing neurons in a primary culture system of the rat accessory olfactory bulb by co-culture with vomeronasal pockets
通过与犁鼻袋共培养,增加大鼠副嗅球原代培养系统中含有酪氨酸羟化酶的神经元的数量
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Muramoto K.;Osada T.;Kato-Negishi M.;Kuroda Y.;Ichikawa M.
- 通讯作者:Ichikawa M.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MORI Yuji其他文献
Determination of Severe Peach Allergens, Gibberellin-Regulated Protein, and Lipid Transfer Protein, Using Monoclonal Antibodies
使用单克隆抗体测定严重桃过敏原、赤霉素调节蛋白和脂质转移蛋白
- DOI:
10.3177/jnsv.68.221 - 发表时间:
2022 - 期刊:
- 影响因子:1.6
- 作者:
OKAZAKI Fumiko;MOMMA Keiko;HIRAKAWA Yuki;KAWAI Natsuki;YAMAGUCHI-MURAKAMI Yukie;ADACHI Reiko;MORI Yuji;KONDO Yasuto;NARITA Hiroshi - 通讯作者:
NARITA Hiroshi
MORI Yuji的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MORI Yuji', 18)}}的其他基金
Synthetic study of gymnocin-B, a polycyclic ether toxin produced by a red tide dinoflagellate
赤潮甲藻产生的多环醚毒素gymnocin-B的合成研究
- 批准号:
20K05503 - 财政年份:2020
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development and dissemination of generic activities to improve children's running and throwing abilities
开发和传播通用活动以提高儿童的跑和投掷能力
- 批准号:
17K04769 - 财政年份:2017
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study on Aspects of communication among Visually Handicapped and Sighted Climbers
视障和视力正常登山者之间沟通方面的研究
- 批准号:
23653147 - 财政年份:2011
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Control of physiological function and behavior by mammalian pheromone
哺乳动物信息素对生理功能和行为的控制
- 批准号:
21228006 - 财政年份:2009
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
Synthetic Studies on Bioactive Polycyclic Ethers
生物活性多环醚的合成研究
- 批准号:
21590029 - 财政年份:2009
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
On the Sense of Community Represented in the Conversation among Participants in Outdoor Educational activities
论户外教育活动参与者对话中所体现的社区意识
- 批准号:
17530363 - 财政年份:2005
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Synthetic studies of bioactive marine polycyclic ethers
生物活性海洋多环醚的合成研究
- 批准号:
15590028 - 财政年份:2003
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Synthetic studies of polycyclic ether marine toxins
多环醚海洋毒素的合成研究
- 批准号:
12672074 - 财政年份:2000
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Organic Synthesis Using Oxiranyl Anions
使用环氧乙烷基阴离子的有机合成
- 批准号:
09672175 - 财政年份:1997
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mammalian Reproductive Pheromone : Isolation and Study on Central Action.
哺乳动物生殖信息素:中枢作用的分离和研究。
- 批准号:
09460124 - 财政年份:1997
- 资助金额:
$ 359.92万 - 项目类别:
Grant-in-Aid for Scientific Research (B)