Multidimensional Electroseparation Systems for the analysis of complex bilogical samples

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The analysis of biological proteomic and metaboleomic samples is difficult due to the enormous number of components and their low abundance. Two-dimensioal electrophoresis has many limitations with regard to sensitivty, dynamic range and automation to mass spectrometry, while chromatographic two-dimensional systems are inefficient and time consuming. This proposal aims at developing new technology for proteomic analyses by deveoping a multidimensional electroseparation system to provide highly efficient, rapid and sensitive analysis of proteomic samples.