Single Molecule Mechanics and Computer Modeling of Cascading System of Biological Information Transfer

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The aim of this project is to perform mechanically quantitative experiments to clarify the mechanical and wound healing characteristics of the cytoskeletal and contribute to the single cell manipulations and surgery. We used a newly developed nano-mechanical methods to measure the different mechanical properties of the red blood cell and fibroblast(especially those of actin stress fibers) and constructed mechanical models to simulate the results. We obtained solid mechanical evidence that showed strong association of stress fibers with cortical actomyosin layer. This association forms the basis for the cytoskeleton and cell membrane cooperation during cell locomotion and information transfer.