Analysis of mucosal immunity inducement system associated CCL20/CCR6 in upper respiratory tract

上呼吸道CCL20/CCR6相关黏膜免疫诱导系统分析

• 批准号: 20791204
• 负责人: ABE Nobuyuki
• 金额: $ 1.75万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791204/
• 关键词: 鼻科学; 上気道; 粘膜免疫; MIP-3α; CCL20; 経鼻ワクチン; 樹状細胞; ケモカイン

BALB/c mice were immunized intranasally OVA and MIP-3α/CCL20. The dendritic cell was induced to NALT in the eminence for an immunohistochemistry . However, OVA specific immune response of IgG and IgA was not induced in the examination of ELISA. It was suggested not to have to the adjuvant effect in the passing nosal vaccine though MIP-3α/CCL20 was able to induce the dendritic cell from this to the immunity inducement tissue.

用卵清蛋白和MIP3α/CCL20滴鼻免疫BALB/c小鼠。将树突状细胞诱导成NALT，进行免疫组织化学染色。但在EL ISA检测中未诱导出OVA特异性的免疫应答。虽然MIP-3α/CCL20能诱导树突状细胞由此产生免疫诱导组织，但在疫苗传递过程中不具有佐剂作用。

项目成果

両側視力障害を来し不幸な転帰をたどった蝶形骨洞真菌症の1例

蝶窦真菌病伴双侧视力障碍不幸结局一例

• 发表时间: 2008
• 作者: Izawa;S.;Sugaya;N.;Shirotsuki;K;et.al.;末谷健志;安倍伸幸
• 通讯作者: 安倍伸幸