Impact of depressive symptoms in diabetic patients. Fukuoka Diabetes Registry

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Depression has been reported to be frequently associated with diabetes mellitus. However, the large-scale epidemiological studies have not been performed in our country. Fukuoka Diabetes Registry, a prospective cohort study, composing of 5131 diabetic patients showed 8.9% of participants having depressive symptoms. As a nondiabetic controlgroup, the Hisayama study revealed 4.0% of residents with depressive symptoms. After controlling for confounding factors, odds ratio for the presence of depressive symptoms was 2.6 in diabetic patients. Furthermore, diabetic patients with depressive symptoms have unhealthy life style including diet and exercise as well as obesity, insulin resistance, poor glycemic control, hypoglycemia and diabetic complications as compared with those without depressive symptoms. Finally, the survival rate was significantlyworse in diabetic patients with depressive symptoms than those without. The present study emphasizes the importance of depression in treatment of diabetes mellitus.