Microcirculation in pancreatic islets and adipose tissue

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Islet of Langerhans is a small organ scattered through the pancreas. Islet has a unique microvascular system and its blood flow is meticulously regulated by some mechanisms. Glucose causes an increase in islet blood flow. In a repetitive administration of glucose, the increase in islet blood flow was smaller in the second administration than the first one. In addition, anti-diabetic and hypertensive medications affected islet blood flow, respectively. Finally, ethanol intakes during pregnancy induced impaired growth of pancreas without affecting islet blood flow in rats.