Development and medical applications of water-soluble supramolecular polymer utilizing molecular techniques of Spiroborates

利用螺硼酸盐分子技术开发水溶性超分子聚合物及其医学应用

• 批准号: 23790035
• 负责人: KAWAHATA Masatoshi
• 金额: $ 2.41万
• 依托单位: Tokushima Bunri University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790035/
• 关键词: 有機化学; 分子認識; 構造・機能材料; 自己組織化; 合成化学; ナノ材料

As part of the new material development, including medical materials using supramolecular polymer, an alternative fat-soluble supramolecular polymer that already reported as "twinbowl", the research of preparation of water-soluble supramolecular polymer, crown ether-like spiroborate anions host, which is expected more robust than general crown ethers was perfomed. We prepared the precursor compound for the final cyclization step to give the crown ethers like spiroborate anion. Although the targeted cyclic spiroborate anion was not obtained, from many experimental trials, we found coexistence of suitable template molecule cations is very important in the cyclization reaction.

作为新材料开发的一部分，包括使用超分子聚合物的医疗材料，这是一种替代性脂溶性超分子聚合物，已经报道为“ Twinbowl”，这是水溶性超分子聚合物，皇冠以太螺旋体式螺旋体性阴离子的准备的研究，预计比一般的冠状Ethers Ethers performed the Ethers the Ethers perfomed the Ethers perfomed。我们为最终的环化步骤准备了前体化合物，以使冠状动脉像螺旋形阴离子一样。尽管未获得靶向的环状螺旋形阴离子，但从许多实验试验中，我们发现合适的模板分子阳离子共存在环化反应中非常重要。

项目成果

Crystal Structures of D3-Symmetric Tris(spiroborate) Twin Bowl with Ammonium Cations

铵阳离子 D3-对称三(螺硼酸)双碗的晶体结构

• 发表时间: 2011
• 作者: Masatoshi Kawahata;Kumiko Kadomoto;Hiroshi Danjo;Kentaro Yamaguchi
• 通讯作者: Kentaro Yamaguchi