Development and medical applications of water-soluble supramolecular polymer utilizing molecular techniques of Spiroborates

利用螺硼酸盐分子技术开发水溶性超分子聚合物及其医学应用

• 批准号: 23790035
• 负责人: KAWAHATA Masatoshi
• 金额: $ 2.41万
• 依托单位: Tokushima Bunri University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790035/
• 关键词: 有機化学; 分子認識; 構造・機能材料; 自己組織化; 合成化学; ナノ材料

As part of the new material development, including medical materials using supramolecular polymer, an alternative fat-soluble supramolecular polymer that already reported as "twinbowl", the research of preparation of water-soluble supramolecular polymer, crown ether-like spiroborate anions host, which is expected more robust than general crown ethers was perfomed. We prepared the precursor compound for the final cyclization step to give the crown ethers like spiroborate anion. Although the targeted cyclic spiroborate anion was not obtained, from many experimental trials, we found coexistence of suitable template molecule cations is very important in the cyclization reaction.

作为新材料开发的一部分，包括使用超分子聚合物的医用材料，一种已被报道为双碗状的替代脂溶性超分子聚合物，进行了制备水溶性超分子聚合物-冠醚状螺硼阴离子主体的研究，预计将比普通冠醚更强健。我们制备了用于最终环化步骤的前驱体化合物，以得到螺硼酸根等冠醚。虽然没有得到目标的环状螺硼酸根阴离子，但通过大量的实验，我们发现合适的模板分子阳离子的共存在环化反应中是非常重要的。

项目成果

Crystal Structures of D3-Symmetric Tris(spiroborate) Twin Bowl with Ammonium Cations

铵阳离子 D3-对称三(螺硼酸)双碗的晶体结构

• 发表时间: 2011
• 作者: Masatoshi Kawahata;Kumiko Kadomoto;Hiroshi Danjo;Kentaro Yamaguchi
• 通讯作者: Kentaro Yamaguchi

Tris(spiroborate)-type anionic nanocycles.

• DOI: 10.1002/asia.201200162
• 发表时间: 2012-07
• 期刊: Chemistry, an Asian journal
• 作者: H. Danjo;Natsuyo Mitani;Y. Muraki;M. Kawahata;I. Azumaya;K. Yamaguchi;T. Miyazawa

Preparation of Tris(spiroorthocarbonate) Cyclophanes as Back to Back Ditopic Hosts

作为背靠背双位宿主的三(螺原碳酸酯)环烷的制备

• DOI: 10.1021/ol4006882
• 发表时间: 2013
• 期刊: Org. Lett.
• 影响因子: 5.2
• 作者: Hiroshi Danjo;Kazuhisa Iwaso;Masatoshi Kawahata;Kazuaki Ohara;Toshifumi Miyazawa;Kentaro Yamaguchi
• 通讯作者: Kentaro Yamaguchi