The development of a new therapy for diabetic retinopathy targeting the receptor-associated prorenin system

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The present study for the first time demonstrated that reactive oxygen species derived from ischemia-reperfusion injury didn't activate the receptor-associated prorenin system in the retina. Moreover, the statistical analysis using the data form the patients with or without diabetes clearly demonstrated that the higher HbA1c and blood pressure were largely associated with the prorenin concentration in the blood. A further experiment is still being carried out using extracted porcine retinal arteriole in order to determine the role of prorenin in the regulation of retinal circulation.