Moleculer mechanism of Hepatocarcinogenesis and Development : Combined Analysis with Kupffer phase Contrast-enchanced US and Gene Expression.

肝癌发生和发展的分子机制：库普弗相增强超声和基因表达的联合分析。

• 批准号: 23650312
• 负责人: KUDO Masatoshi
• 金额: $ 2.41万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650312/
• 关键词: 超音波医科学; ソナゾイド造影超音波; 肝細胞癌; クッパー細胞; 遺伝子多型

OATP8 epression is observed in dysplastic nodule, but not in early hepatocellular carcinoma (e-HCC),which is shown as low intense on kupffer phase contrast-enhanced US. In addition,Glypican3,HSP70,GS,CAP2,Bmi-1 are highly expressed in e-HCC during multistep hepatocarcinogenesis.

OATP 8在不典型增生结节中表达，但在早期肝细胞癌（e-HCC）中未观察到，其在Kupffer期对比增强US上显示为低强度。此外，Glypican 3、HSP 70、GS、CAP 2、Bmi-1在e-HCC的多步癌变过程中高表达。

项目成果

Novel Association between global DNA hypomethylation and chromosomal instability phenotype in human hepatocellular carcinoma

人类肝细胞癌中整体 DNA 低甲基化与染色体不稳定表型之间的新关联

• 发表时间: 2012
• 作者: Yamada A;Horimatsu T;Okugawa Y;Nishida N;Kou T;Kusaka T;Honjo H;Amanuma Y;Kikuchi O;Muto M;Goel A;Boland CR.;Naoshi Nishida;Naoshi Nishida;西田直生志;Naoshi Nishida;Naoshi Nishida
• 通讯作者: Naoshi Nishida

Usefulness of Combination of Imaging Modalities in the Diagnosis of Hepatocellular Carcinoma Using Sonazoid®-Enhanced Ultrasound, Gadolinium Diethylene-Triamine-Pentaacetic Acid-Enhanced Magnetic Resonance Imaging, and Contrast-Enhanced Computed Tomography

• DOI: 10.1159/000333264
• 发表时间: 2011-01-01
• 期刊: ONCOLOGY
• 影响因子: 3.5
• 作者: Alaboudy, Alshimaa;Inoue, Tatsuo;Kudo, Masatoshi
• 通讯作者: Kudo, Masatoshi

Effect of Vitamin K2 on the Recurrence of Hepatocellular Carcinoma

• DOI: 10.1002/hep.24430
• 发表时间: 2011-08-01
• 期刊: HEPATOLOGY
• 影响因子: 13.5
• 作者: Yoshida, Haruhiko;Shiratori, Yasushi;Omata, Masao
• 通讯作者: Omata, Masao

apan's successful model of nationwide hepatocellular carcinoma surveillance highlighting the urgent need for global surveillance.

日本全国性肝细胞癌监测的成功模式凸显了全球监测的迫切需要。

• 发表时间: 2012
• 期刊: Liver Cancer
• 影响因子: 13.8
• 作者: Y.Tanaka;N.Shinsei;M.Ishida;Y.Uesugi;J. Wada and S. Okabe;朴美貞;Kudo M
• 通讯作者: Kudo M

Assessment of Gd-EOB-DTPA–enhanced MRI for HCC and Dysplastic nodule and comparison of detection sensitivity versus MDCT.

Gd-EOB-DTPA 增强 MRI 对 HCC 和发育不良结节的评估以及检测灵敏度与 MDCT 的比较。

• 发表时间: 2012
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Hagiwara S;Kobayashi S;Tsuchida S;Kudo M;Inoue T
• 通讯作者: Inoue T