Molecular Mechanism and Blood Flow Imaging of the Formation of Angioarchitech titure during the Occurrence and Progression of Hepatocellular Carcinoma.

肝细胞癌发生发展过程中Angioarchitech结构形成的分子机制及血流成像。

• 批准号: 10470143
• 负责人: KUDO Masatoshi
• 金额: $ 5.12万
• 依托单位: Kinki University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470143/
• 关键词: hepatocellular carcinoma; tumor vessel; tumor neovascularization; hemodynamics; multicenter occurrence; harmonic imaging; angioarchitecture; angiogenic factor; 分子機構; 腫瘍血流; 血流画像; 画像診断; 肝発癌

1. Change of Intranodular Blood Flow During the Occurrence and Multistep Progression of Hepatocellular Carcinoma.Hepatocellular carcinoma(HCC)occurs as a hyperplastic nodule at its initiation of cancer. During multistep progression, hyperplastic nodule develops to the early well-differentiated HCC, and finally to advanced moderately differentiated HCC.Consistent with this progression, intranodular hemodynamic also changes, from arterially hypovascular and portally iso-perfusion(type I)to hypoperfusion state both from artery and portal vein(type II). Then it develops to the isovascular(type III)and to the classical hypervascular HCC(type II). This alteration can be detected by in vivo vascular imagings, such as US angiography, CTA, and CTAP.2. Hemodynamic AnalysisIn addition to invasive vascular imaging, contrast harmonic imaging with intravenous injection of ultrasound contrast agent is extremely useful in the detection of intra nodular vascularity, both arterial and portal venous flow.

1.肝细胞癌发生及多阶段发展过程中结节内血流的变化肝细胞癌（HCC）在其癌的起始阶段是一个增生性结节。在多步骤进展过程中，增生结节发展为早期高分化HCC，最后发展为晚期中分化HCC，与此相一致，结节内血流动力学也发生变化，从动脉和门静脉等灌注状态（I型）到动脉和门静脉的低灌注状态（II型）。然后发展为等血管型（III型）和典型的富血管型（II型）。这种改变可以通过体内血管成像检测，如US血管造影、CTA和CTAP。血流动力学分析除了侵入性血管成像，静脉注射超声造影剂的对比谐波成像在检测结节内血管、动脉和门静脉血流方面非常有用。

项目成果

Kudo M: "Imaging diagnosis of hepatocellular carcinoma." Seminors in Liver Disease. (in press).

工藤 M：“肝细胞癌的影像诊断。”

Yamamoto T, Kudo M, et al.: "Hepatocellular carcinomas intected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)

Yamamoto T、Kudo M 等人：“感染新型 TT DNA 病毒的肝细胞癌缺乏病毒整合。”Biochem Bioph Res Co. 251. 339-343 (1998)

Tochi H, Kudo M, et al.: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall"AJR. 172. 1249-1253 (1999)

Tochi H、Kudo M 等人：“脂肪肝中的局灶性保留区域与胆囊壁的肝内传出血流之间的关联”AJR。

Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)

Kudo M：“肝细胞癌和癌前/交界性病变的影像诊断。”肝病研讨会。

Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)

Kudo M：“Riedel 肝叶及其临床意义。”内科。