NLS-indepedent nucleocytoplasmic transport pathways of macromolecules

不依赖 NLS 的大分子核质转运途径

基本信息

项目摘要

Transport of macromolecules between the cytoplasm and the nucleus across the nuclear envelope occurs through the nuclear pore complex (NPC). Transport substrates bind to soluble receptors and subsequently pass the NPC by an energy- and Ran-dependent mechanism. The Ran GTPase regulates association and dissociation of the substrates with the receptors. The best understood transport pathway is the import of nuclear localization signal (NLS)-containing proteins into the nucleus. The NLS-receptor consists of two subunits (importin-alpha and beta). Other, more specialized transport pathways are not importin-dependent. Ribosomal proteins directly bind to various importinbeta-related receptors. The aim of this project is to investigate nuclear import of ribosomal proteins in general and to analyze the role of importin-beta-related receptors in ribosomal protein import in vivo and in vitro. Another goal is the functional characterization of several novel importin-beta-related receptors. Here, we focus on the identification of the respective transport substrates.
大分子在细胞质和细胞核之间穿过核膜的运输通过核孔复合体(NPC)发生。转运底物与可溶性受体结合,随后通过能量和Ran依赖性机制通过NPC。Ran GT3调节底物与受体的结合和解离。最好理解的转运途径是将含有核定位信号(NLS)的蛋白质输入到细胞核中。NLS受体由两个亚基(输入素-α和β)组成。其他更专门的运输途径不依赖于进口。核糖体蛋白直接与各种importinbeta相关受体结合。该项目的目的是研究核糖体蛋白的核输入,并分析体内和体外输入β相关受体在核糖体蛋白输入中的作用。另一个目标是几个新的输入β相关受体的功能特性。在这里,我们专注于识别各自的运输基板。

项目成果

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Professor Dr. Gabriel Schlenstedt其他文献

Professor Dr. Gabriel Schlenstedt的其他文献

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{{ truncateString('Professor Dr. Gabriel Schlenstedt', 18)}}的其他基金

Regulation of nucleocytoplasmic transports by sumoylation
通过苏酰化调节核细胞质运输
  • 批准号:
    235832271
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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