Light-activatable cytostatic compounds

光激活细胞抑制化合物

• 批准号: 510982619
• 负责人: Professor Dr. Alexander Heckel
• 金额: --
• 依托单位: Institut für Organische Chemie und Chemische Biologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/510982619?language=en
• 关键词: Light; activatable; cytostatic; compounds

Making cytostatic compounds selective is a big challenge. In the past 20 years, my group has worked on making DNA and RNA light-activatable in order to regulate their biological activity with exact control over space, time and dose. Latest progress in mice, neuronal tissue and human blood have made us confident that nucleoside-based cytostatic compounds could be regulated in a similar way. With this project, we want to try to transfer our knowledge now to this class of substances.

使细胞抑制化合物具有选择性是一个巨大的挑战。在过去的20年里，我的团队一直致力于使DNA和RNA可光激活，以便通过精确控制空间，时间和剂量来调节它们的生物活性。在小鼠、神经元组织和人类血液中的最新进展使我们相信，基于核苷的细胞抑制化合物可以以类似的方式进行调节。通过这个项目，我们想尝试将我们的知识转移到这类物质上。