Injectable scaffolds for treatments of neurological disorders

用于治疗神经系统疾病的可注射支架

• 批准号: DP0450618
• 负责人: Prof John Forsythe
• 金额: $ 20.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0450618
• 关键词: Injectable; scaffolds; treatments; neurological; disorders

Cell replacement therapies offer potentially effective treatments for a host of neurological disorders but a major obstacle confronting their development is to ensure appropriate connections are formed within the brain. This proposal aims to utilize injectable biodegradable polymers, to demonstrate the feasibility of assisting neural cells and stem cells to bridge glial scars or significant distances in the brain and repair damaged neural pathways. This proposal will focus on naturally occurring polysaccharides, which will act as "scaffolds" for the growing neurones. The role the scaffolds play in regulating neurite extension will be investigated in vitro and in vivo.

细胞替代疗法为许多神经系统疾病提供了潜在的有效治疗方法，但其发展面临的主要障碍是确保在大脑内形成适当的连接。该提案旨在利用可注射的可生物降解聚合物，证明辅助神经细胞和干细胞桥接胶质瘢痕或大脑中的显著距离并修复受损神经通路的可行性。这项建议将集中在天然存在的多糖，这将作为“支架”的生长神经元。将在体外和体内研究支架在调节神经突延伸中所起的作用。