A novel regulator of growth signalling in Drosophila

果蝇生长信号的新型调节剂

• 批准号: DP160102797
• 负责人: Prof Coral Warr
• 金额: $ 26.59万
• 依托单位: University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102797
• 关键词: novel; regulator; growth; signalling; Drosophila

This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.

该项目旨在增加对生长因子激素如何调节生长的理解。在动物中，生长是由分泌的肽激素激活的信号通路控制的。一种新的果蝇生长调节因子，膜攻击复合物/穿孔素样（MACPF）蛋白Torso样，已被鉴定。该项目旨在揭示躯干样功能如何调节生长，从而揭示这种蛋白质家族在所有动物中可能发挥的作用。这些发现有望为改变生长因子活性提供关键见解，这种活性在人类癌症和生长障碍中经常失调，并可能设计新的策略来干扰昆虫发育以控制害虫。