Phenotypic and functional characterization of pro-fibrotic and pro-regenerative T cells in models of renal fibrosis (B04)

肾纤维化模型中促纤维化和促再生 T 细胞的表型和功能特征 (B04)

• 批准号: 517500010
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin II
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/517500010?language=en
• 关键词: Phenotypic; functional; characterization; pro; fibrotic

Fibrosis caused by repetitive injuries is considered a major cause of organ failure. We developed an experimental system to study repetitive renal insults and found strong evidence for the generation of a “fibrotic memory”. CD4+ memory T cells and IL-3 were identified as key players in this process. In the next funding period, we would like to better understand how these T cells are activated and what downstream pathways lead to matrix production. In addition, we will investigate whether there are also counterbalancing anti-fibrotic T cells and study the impact of sodium chloride on fibrosis development.

反复损伤引起的纤维化被认为是器官衰竭的主要原因。我们开发了一个实验系统来研究重复的肾脏侮辱，并发现了“纤维化记忆”产生的有力证据。CD4+记忆T细胞和IL-3被确定为在这一过程中的关键角色。在下一个资助期，我们希望更好地了解这些T细胞是如何被激活的，以及哪些下游途径导致基质产生。此外，我们还将研究是否也存在抗肝纤维化的T细胞，并研究氯化钠对纤维化发展的影响。