权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A basic and clinical research of the referred pain in the oro-facial region

口面部牵涉痛的基础与临床研究

基本信息

批准号：
58440072
负责人：
SUNADA Imao
金额：
$ 9.34万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1983
资助国家：
日本
起止时间：
1983 至 1985
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-58440072/
关键词：
referred pain etched dentin surface functional single fibers cortical primary somatosensory area ventro-basal nuclear complex tooth pulp driven neurons convergence 知覚の異常

项目摘要

1. The present study was designed to investigate the basic mechanisms of the referred pain in the oro-facial region. Cats were used in our experiments. The results obtained were as follows:(1). It was found that mechanical stimuli applied to the etched dentin surface of the canine evoked impulses in the functional single fibers with fast conduction velocities dissected from the inferior alveolar nerve, and that slow-conducting dental nerve fibers were relatively insensitive to mechanical stimulation.(2). Local application of the chemicals such as potassium oxalate, alminium chloride and Ag(NH3)2OH solution resulted in the reduction of number of spikes evoked by mechanical stimulation to the exposed dentin, and the effect was more remarkable when they were applied iontophoretically.(3). Spontaneous impulses recorded from the masseteric nerve were modified by electrical stimuli applied to the canine tooth pulp and they were increased in most cases.(4). The tooth pulp driven neurons(TPDNs) were identified in the cortical primary somatosensory area(SI) and in the ventro-basal nuclear complex of the thalamus. One half of these SI neurons was shown to be driven by the impulses not only from the tooth pupl but from the other oro-facial regions. Such convergence in the central nervous system could cause the referred pain observed in the orofacial region.2. The clinical investigation of the patients suffering from the referred pain in the oro-facial region suggested that the pain was reduced or disappeared after the appropriate treatment of the pulpal or periodontal diseases. It was also observed that the patients sometimes complained of the hypersensitivity in the referred region at the first stage of the referred pain.

1.本研究旨在探讨口面部牵涉痛的基本机制。猫被用于我们的实验。结果表明：（1）.结果发现，机械刺激施加到蚀刻的牙本质表面的犬诱发冲动的功能性单纤维与快传导速度解剖下牙槽神经，和慢传导的牙神经纤维是相对不敏感的机械刺激。（二）、局部应用草酸钾、氯化铝和Ag（NH3）2 OH溶液可减少机械刺激暴露牙本质诱发的棘波数，且以离子导入作用更为显著。（三）、咬肌神经记录的自发脉冲被施加到犬牙髓的电刺激修改，并且在大多数情况下增加。（四）、牙髓驱动神经元（TPDN）位于皮层初级躯体感觉区（SI）和丘脑腹侧-基底核复合体。这些SI神经元中的一半被证明不仅是由来自牙齿瞳孔的脉冲驱动，而且是由来自其他口面部区域的脉冲驱动。这种中枢神经系统的会聚可引起口面部的牵涉痛。对口面部牵涉痛患者的临床研究表明，经适当的牙髓或牙周病治疗后，疼痛减轻或消失。还观察到，患者有时会在牵涉痛的第一阶段抱怨牵涉区域的超敏反应。