A Basic and Clinical Study on the Pathogenesis and Nature of the Periapical Lesions.

Sunada发现一些巨噬细胞样细胞浸润到实验诱导的根尖周围病变中，且大多数呈ia抗原阳性。Uno报道了超氧化过程与根尖周围病变的发病机制有关。Kawanami发现，根尖的内毒素主要分布在根管和牙本质壁的浅层。上野证明了根管的完全消毒对于减少根尖周炎症是必不可少的。关于根管治疗的临床成功，Tamazawa做了有趣的发现。Maita发现根管系统腐胺浓度与根尖周围病变患者临床观察到的疼痛相关。斋藤证实，在根尖周围病变渗出液中，多形核白细胞的吞噬能力弱于外周血流中的吞噬能力。K. Matsumoto在根尖周围病变处观察到一些炎症细胞。Nakamura发现临床症状与根尖周围的病理变化有一定的相关性。Ebisu甚至在准备好的根管中也发现了厌氧菌，并提示细菌的存在与临床症状之间存在相关性。Murayama表示，根管内的细菌数量和种类远少于牙周袋内的细菌。Yamamoto和Soh发现，使用超声器械扩大根管比任何其他扩大方法更有效，但它在根尖孔外产生更多的挤压物质。Aono证实在实验诱导的根尖周围病变中存在大量含igg的细胞。Nagasawa展示了大鼠和人类上颌第一磨牙的根尖结构的相似性。H. Matsumoto展示了产生热致根尖周病变的困难。Nagaoka认为拟杆菌属（Bacteroides）引起了根尖周围炎症，并认为免疫过程在其发展中起重要作用。少

Sunada found that some macrophage-like cells infiltrated into the experimentally induced periapical lesions, and that most of them were Ia-antigen positive. Uno reported that superoxidating process was related to the pathogenesis of the periapical lesions. Kawanami revealed most of endotoxin in the root apex was found in the root canal and the superficial layer of the dentinal wall. Ueno demonstrated that the perfect disinfection of the root canal was essential for the reduction of periapical inflammation. Tamazawa made interesting findings concerning the clinical success of the root canal treatment. Maita found the correlation of putrescine concentration in the root canal system with clinically observed pain in patients with periapical lesions. Saito demonstrated that the phagocytic ability of polymorphonuclear leukocytes in the exudation from periapical pathosis was weaker than that in the peripheral blood flow. K. Matsumoto observed some inflammatory cells in the periapical lesion u … More sing an electron microscope. Nakamura found that there was some correlations between clinical symptoms and periapical pathological changes. Ebisu identified anaerobic bacteria even in the prepared root canals, and suggested that there were correlations between the presence of bacteria and clinical symptoms. Murayama showed that the numbers and species of bacteria in the root canal were much less than those in the periodontal pockets. Yamamoto and Soh found that the enlargement of the root canal using ultrasonic apparatus was more effective than any other enlarging method, while it produced much more extruded substance beyond the apical foramen. Aono demonstrated that a lot of IgG-containing cells in the experimentally induced periapical lesions. Nagasawa showed the similarity of the root end structures between the rat and human maxillary first molars. H. Matsumoto showed the difficulties of producing heat-induced periapical lesions. Nagaoka recognized that Bacteroides species caused the periapical inflammation, and suggested that the immunological process played an important role in its development. Less