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A Basic and Clinical Study on the Pathogenesis and Nature of the Periapical Lesions.

根尖周病变发病机制和性质的基础和临床研究。

基本信息

批准号：
01304046
负责人：
SUNADA Imao
金额：
$ 12.93万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

Sunada found that some macrophage-like cells infiltrated into the experimentally induced periapical lesions, and that most of them were Ia-antigen positive. Uno reported that superoxidating process was related to the pathogenesis of the periapical lesions. Kawanami revealed most of endotoxin in the root apex was found in the root canal and the superficial layer of the dentinal wall. Ueno demonstrated that the perfect disinfection of the root canal was essential for the reduction of periapical inflammation. Tamazawa made interesting findings concerning the clinical success of the root canal treatment. Maita found the correlation of putrescine concentration in the root canal system with clinically observed pain in patients with periapical lesions. Saito demonstrated that the phagocytic ability of polymorphonuclear leukocytes in the exudation from periapical pathosis was weaker than that in the peripheral blood flow. K. Matsumoto observed some inflammatory cells in the periapical lesion u … More sing an electron microscope. Nakamura found that there was some correlations between clinical symptoms and periapical pathological changes. Ebisu identified anaerobic bacteria even in the prepared root canals, and suggested that there were correlations between the presence of bacteria and clinical symptoms. Murayama showed that the numbers and species of bacteria in the root canal were much less than those in the periodontal pockets. Yamamoto and Soh found that the enlargement of the root canal using ultrasonic apparatus was more effective than any other enlarging method, while it produced much more extruded substance beyond the apical foramen. Aono demonstrated that a lot of IgG-containing cells in the experimentally induced periapical lesions. Nagasawa showed the similarity of the root end structures between the rat and human maxillary first molars. H. Matsumoto showed the difficulties of producing heat-induced periapical lesions. Nagaoka recognized that Bacteroides species caused the periapical inflammation, and suggested that the immunological process played an important role in its development. Less

Sunada等发现实验性根尖周病变中有巨噬细胞样细胞浸润，且大多数为Ia抗原阳性。Uno等报道过氧化过程与根尖周病变的发生有关。Kawanami发现，根尖内毒素主要分布在根管和牙本质壁的浅层。Ueno证明了根管的完美消毒对于减少根尖周炎是必不可少的。Tamazawa对根管治疗的临床成功做出了有趣的发现。Maita发现根管系统中腐胺浓度与根尖周病变患者临床观察到的疼痛相关。Saito证明根尖周病变渗出液中多形核白细胞的吞噬能力弱于外周血。K.松本观察到根尖周病变中有一些炎性细胞， ...更多信息用电子显微镜。中村发现临床症状与根尖周病变之间存在一定的相关性。Ebisu甚至在准备好的根管中鉴定出厌氧菌，并提出细菌的存在与临床症状之间存在相关性。Murayama指出，根管中的细菌数量和种类远少于牙周袋中的细菌。Yamamoto和Soh发现，使用超声波器械进行根管扩大比任何其他扩大方法都有效，但它产生了更多的超出根尖孔的挤出物。Aono证明实验诱导的根尖周病变中存在大量含IgG的细胞。Nagasawa发现大鼠和人类上颌第一磨牙的根端结构相似。H.松本表现出的困难，产生热诱导根尖周病变。长冈认识到类杆菌属引起了尖周炎症，并认为免疫过程在其发展中发挥了重要作用。少