Androgenic regulation of acyl-CoA dehydrogenase expression
Androgenic regulation of acyl-CoA dehydrogenase expression
批准号:
09044269
负责人:
SEYAMA Yousuke
金额:
$3.52万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for international Scientific Research
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
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英文摘要
Sexual differences are observed in the lipid composition of golden hamster Harderian land. Male gland contains straight chain fatty acids, but that of female additionally contains branched chain ones. These differences were generated by the androgenic regulation of acyl-CoA dehydrogenases ; isovaleryl-CoA dehydrogenase (IVD) and short/branched chain acyl-CoA dehydrogenase (SBCAD), which are the key enzymes for the formation of branched chain fatty acids in the gland.In this study, we showed that the activity of these two enzymes were regulated by androgen. This regulation was tissue-specific and occurred at the step of gene expression. We also found that androgen receptors (AR) were induced by androgen in Harderian gland, and this induction was preceded the induction of IVD and SBCAD.We also determined the sequence of hamster AR cDNA and found homologous regions which were responsible for the auto-regulation of human AR.
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Yokoyama Y., Ozawa S., Seyama Y.et al.: "Enhancement of apoptosis in developing chick neural retina cells by basic fibroblast growth factor." J.Neurochem.68. 2212-2215 (1997)
Yokoyama Y.、Ozawa S.、Seyama Y.等人:“通过碱性成纤维细胞生长因子增强发育中的小鸡神经视网膜细胞的凋亡。”
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横山嘉子 等: "Enhancement of apoptosis in developing chick neural retina cells by basic fibroblast growth factor." J.Neurochem.68. 2212-2215 (1997)
Yoshiko Yokoyama 等人:“通过碱性成纤维细胞生长因子增强发育中的鸡神经视网膜细胞的细胞凋亡。”J.Neurochem.68(1997)。
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Uchijima, Y. et al.: "Androgenic control of acyl-CoA dehydrgenase expression." Chemistry and Physics of Lipids. 88(2). 139-139 (1997)
Uchijima, Y. 等人:“酰基辅酶 A 脱氢酶表达的雄激素控制。”
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Hida, A., Uchijima, Y.and Seyama, Y.: "Sexual differences in branched chain amino acid metabolism into fatty acids and cholesterol in Harderian gland of golden hamster." J.Biochem.124. 648-653 (1998)
Hida, A.、Uchijima, Y. 和 Seyama, Y.:“金仓鼠哈德氏腺中支链氨基酸代谢为脂肪酸和胆固醇的性别差异。”
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Uchijima Y., Hida A., Ozawa, S.et al.: "Androgenic control of acyl-CoA dehydrogenase and its utilization for assaying androgenic activity." Chem.Phys.Lipids. 94. 176 (1998)
Uchijima Y.、Hida A.、Ozawa, S.等人:“酰基辅酶A脱氢酶的雄激素控制及其用于测定雄激素活性的用途。”
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共 18 条
Induction Mechanism of Apoptosis in Cerebrotendinous Xanthomatosis
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Effects of cholestanol on neuronal cell death
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Control of acyl-CoA dehydrogenase expression by androgen.
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Mechanism of cerebellar neuronal cell death in CTX patients
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Identification of sterol 27 hydroxylase gene mutations in CTX patients
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财政年份:1995
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负责人:SEYAMA Yousuke
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Genetic analysis of cerebrotendinous xanthomatosis
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批准号:06044070
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项目类别:Grant-in-Aid for international Scientific Research
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负责人:SEYAMA Yousuke
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依托单位:
Genetic diagnosis of cerebrotendinous xanthomatosis
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财政年份:1992
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负责人:SEYAMA Yousuke
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依托单位:
Pathophysiological investigation on cerebrotendinous xanthomatosis
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批准号:02044044
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项目类别:Grant-in-Aid for international Scientific Research
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财政年份:1990
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Establishment of CTX Model Animal and Survey of its Pathogenesis.
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1990
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负责人:SEYAMA Yousuke
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依托单位:
Harderian Gland as a Model Organ for Study of Circadian Rhythm.
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批准号:62440085
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$9.54万
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财政年份:1987
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负责人:SEYAMA Yousuke
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依托单位:
Development of Diagnosis System of Cerebrotendinous Xanthomatosis
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$5.63万
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财政年份:1986
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负责人:SEYAMA Yousuke
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依托单位:
Harderian Gland as a Model Organ for Study of Lipid Metabolism
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批准号:60480494
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1985
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负责人:SEYAMA Yousuke
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依托单位:
海外基金