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Seroepidemiological study on Ascaris suum infection in humans, an emerging zoonosis causing visceral larva migrans

人类猪蛔虫感染的血清流行病学研究，一种引起内脏幼虫移行症的新出现的人畜共患病

基本信息

批准号：
09470070
负责人：
NAWA Yukifumi
金额：
$ 7.49万
依托单位：
Miyazaki Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Ascaris suum is naturally an intestinal parasite of pigs. Viscerallarva migrans (VLM) characterized as pneumonitis and/or liver dysfunction with marked eosinophilia has been known to occur after experimental or accidental ingestion of A. suum embryonated eggs. However, natural occurrence of VLM due to A. suum has never been reported until our recent discovery of the presence of this disease in the pig-farming area in Kyushu. By the end of 1999, we have found 128 cases of immunoserologically diagnosed VLM probably caused by infection with A. suum. These cases included 2 ocular and 5 CNS involvement. After the informed concent has obtained, seroepidemiological survey was conducted in the pig-farming area in Kyushu; 6 towns in Miyazaki Prefecture and 2 towns in Kagoshima prefecture. The results show that 20-30% of the residents living in pig-farming area were seropositive against A. suum antigen by IgG-ELISA, while those living in non-pig-farming area showed less than 10% seropositivity against A. suum. Because parasitic infection has been supposed to affect and modulate allergic status, we examined the relationship between A. suum infection and allergy in the pig-farming area in Kyushu. For this purpose, specific IgE antibody against cedar pollen and/or mite allergen was measured as well as specific IgG/IgE antibodies against A. suum. The results show that the prevalence of allergic individuals having anti-cedar pollen and/or anti-mite IgE antibody was far greater in A. suum-infected group compared to that in parasite-free group. These results suggest that parasite infection is one of the important risk factor for allergic disease.

猪蛔虫是猪的肠道寄生虫。内脏幼虫移行症（VLM）的特征是肺炎和/或肝功能障碍，伴有显著的嗜酸性粒细胞增多，已知在实验性或意外摄入A后发生。猪胚蛋然而，自然发生的VLM由于A。在我们最近在九州的养猪场发现这种疾病之前，从未报道过猪流感。截至1999年底，我们共发现128例经免疫血清学诊断可能由A. suum。这些病例包括2例眼部和5例中枢神经系统受累。在获得知情同意后，在九州养猪区、宫崎县6个町和鹿儿岛县2个町进行了血清流行病学调查。结果表明，20%~ 30%的养猪区居民血清中有A。非养猪区人群血清学阳性率低于10%。suum。由于寄生虫感染被认为影响和调节过敏状态，我们研究了A。猪感染和过敏的猪养殖区在九州。为此，测定了抗雪松花粉和/或螨过敏原的特异性IgE抗体以及抗A. suum。结果表明，过敏性个体具有抗雪松花粉和/或抗螨IgE抗体的患病率在A.寄生虫感染组与无寄生虫组相比。提示寄生虫感染是变态反应性疾病的重要危险因素之一。