Natural Life Cycle of Gnathostoma Doloresi in Miyazaki Prefecture, with Emphasis on the Route of Infection to the Patients.

宫崎县多洛雷氏颚口虫的自然生命周期，重点是患者的感染途径。

• 批准号: 01570217
• 负责人: NAWA Yukifumi
• 金额: $ 1.41万
• 依托单位: Miyazaki Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570217/
• 关键词: Gnathostoma doloresi; Gnathostomiasis; Miyazaki Prefecture; Life cycle; Route of infection; Final host; Intermediate host; Paratenic host; 人獣共通感染症; 幼虫移行症; ドロレス顎口虫症

In 1988, we found the first confirmed human case of Gnathostoma doloresi infection in Miyazaki Prefecture. In addition, two more confirmed cases were found by the retrospective survey of paraffin-embedded biopsied skin of 7 suspected cases. Up to now, a total of 14 human gnathostomiasis doloresi cases including 4 confirmed cases were found in the central part of Miyazaki Prefecture. Among these 14 cases, 13 cases were anglers or their wife having a common past history of eating raw slice meat of freshwater fishes, mainly Oncorhynchus masou. One case had a past history of eating raw slice meat meat of a snake, Agkistrodon halys. Based on the history of the patients, we conducted a survey to elucidate the natural life cycle of G. doloresi and to identify the source of infection to the patients. The wild boars, Sus scrofa leucomystax, captured in the mountainous areas of Miyazaki Pref. Were infected with G. doloresi with 100% incidence. Artificially hatched L_1 from the intrauterine eggs … More from the adult female worms could grew up into L_3 in the first intermediate host. cold water cyclops. As the second intermediate host and/or the paratenic host, the poisonous snakes, Agkistrodon halys, captured in the mountainous areas of Miyazaki Pref. were infected with G. doloresi L_3 with 100% incidence. The L_3 recovered from A. halys could develop into mature adult worms by an experimental infection in a pig. In addition, a nonpoisonous snake, Elaphe quadrivergata, also harbored G. doloresi L_3. These results suggest that snakes are important in the natural life cycle of this parasite. From the anamnes is of the patients, freshwater fishes are most likely source of infection to the patients. Therefore, we examined two kinds of freshwater fishes, common Japanese name "Yamame", Oncorhynchus masou, and common name "Blue gill" , Lepomis macrochirus, both captured at Hitotsuse River. Although more than 200 each were examined, G. doloresi larvae were not yet found from these fishes. Further extensive survey is necessary for the identification of the source of infection. Less

1988年，我们在宫崎县发现了首例确诊的人类多洛雷氏颚口线虫感染病例。此外，通过对7例疑似病例的石蜡包埋皮肤活检的回顾性调查，又发现了2例确诊病例。截至目前，宫崎县中部地区共发现包括4例确诊病例在内的14例人口颌型多罗瑞斯病例。在这14宗个案中，有13宗是垂钓人士或其妻子，他们均有进食生淡水鱼肉片（主要是虹鳟鱼）的共同过往纪录。1例有生吃蝮蛇肉片史。根据患者的病史，我们进行了一项调查，以阐明G。doloresi，并确定感染源的病人。从日本宫崎县山区捕获的野猪，感染G. doloresi的发病率为100%。L_1从子宫内卵中孵化 ...更多信息 在第一中间宿主中可发育成L_3。冷水独眼巨人在日本宫崎县山区捕获的蝮蛇（Agkistrodon halys）作为第二中间宿主和/或寄生宿主，感染了G. doloresi L_3的发生率为100%。从A.通过对猪进行实验性感染，halys可以发育成成熟蠕虫。此外，一种无毒的蛇Elaphe quadrivergata也携带G. doloresi L_3.这些结果表明，蛇在这种寄生虫的自然生命周期中很重要。从患者的动物来源来看，淡水鱼是最有可能的感染源。因此，我们研究了两种淡水鱼，日本共同名称“Yamame”，Oncorhynchus masou，和共同名称“蓝鳃”，Lepomis macrochirus，都在一津濑川捕获。虽然每一种都有200多个被检测，G.在这些鱼类中尚未发现doloresi幼虫。为了确定感染源，有必要进行进一步的广泛调查。少

项目成果

Nawa,Y.et al.: "Current status of Gnathostome doloresi infection in wild boars captured in Miyazaki prefecture,Japan." Japanese Journal of Parasitology. 38. 385-387 (1989)

Nawa,Y.等人：“日本宫崎县捕获的野猪中颚口虫感染的现状。”

緒方 克己・名和 行文: "講談社 皮膚科診断治療大系(補遺2)" 講談社,

绪方克己、名和幸文：《讲谈社皮肤科诊断和治疗系统（补充2）》讲谈社、

名和 行文 他: "食物より感染する寄生虫症" 治療学. 25. (1991)

Yukifumi Nawa 等人：“通过食物传播的寄生虫”25。（1991）

名和 行文・緒方 克己: "寄生虫疾患の診断法の開発と症例検討" 医薬ジャ-ナル社 神原廣二監修, 247 (1991)

Yukifumi Nawa 和 Katsumi Ogata：“寄生虫病诊断方法的开发和案例研究”Pharmaceutical Journal，由 Koji Kambara 指导，247 (1991)

Nawa,Y.et al.: "The first record of a confirmed human case of Gnathostoma doloresi infection." Journal of parasitology. 75. 166-169 (1989)

Nawa,Y.et al.：“第一个确诊的人类多洛雷颌口虫感染病例的记录。”