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Basic research on the effect that coping behavior against emotional stress has on immunity.

情绪压力应对行为对免疫力影响的基础研究。

基本信息

批准号：
09470209
负责人：
TASHIRO Nobutada
金额：
$ 5.44万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470209/
关键词：
emotion stress hypothalamus coping psychoneuroimmunology サイトカイン

项目摘要

The aim of this study is to examine whether or not an acquired coping behavior to a stressor can prevent the emergence of physical diseases caused by stress. For that purpose, we used emotional stress caused by direct electrical stimulation to the center of emotion in the brain in order to elucidate the effects of switch-off behavior on the changes in immunity under emotional stress.Our study suggested :1. When electrical stimulation to the hypothalamus, which elicits an emotional behavior called restlessness, and is known to be one kind of emotional stress, the number of peripheral blood granulocytes increased while, in contrast, the number of T lymphocytes decreased. These changes in the number of leukocytes in the peripheral blood might indicate that the immune system is in a "battle state". However, if such a "battle state" continues for too long a period, then the immune system may become exhausted.2. When the cat learned switch-off behavior in which the cat was able to turn off the hypothalamic stimulation, then the increase in the number of granulocytes caused by restlessness was suppressed. As a result, appropriate coping behavior to an aversive emotional stress may suppress the induction of unnecessary immunity activation, thereby preventing immune exhaustion.3. A behavioral analysis and the measurement of the plasma concentration levels of cortisol and catecholamines revealed that the effect of the switch-off behavior in immunity was not merely due to the physical exercise of the cat.In general, the suppression of the immune function caused by stress has been reported to possibly enhance the development of such diseases as infections or tumors. Our study suggested that learning an appropriate coping behavior to aversive emotional stress may suppress some of the needless changes in immunity caused by stress, and thereby prevent the onset of stress-related physical diseases.

本研究的目的是检验对压力源的后天应对行为是否可以预防由压力引起的身体疾病的发生。为此，本研究采用直接电刺激大脑情绪中枢的方法，探讨情绪应激下关闭行为对免疫功能的影响。当对下丘脑进行电刺激时，这引起了一种称为不安的情绪行为，并且已知是一种情绪应激，外周血粒细胞的数量增加，而相反，T淋巴细胞的数量减少。外周血中白细胞数量的这些变化可能表明免疫系统处于“战斗状态”。然而，如果这样的“战斗状态”持续太长时间，那么免疫系统可能会变得疲惫不堪。2.当猫学会了关闭行为，其中猫能够关闭下丘脑刺激，然后由不安引起的粒细胞数量的增加被抑制。因此，对厌恶性情绪应激采取适当的应对行为，可以抑制不必要的免疫激活的诱导，从而防止免疫衰竭.行为分析和皮质醇和儿茶酚胺的血浆浓度水平的测量显示，免疫力的关闭行为的影响不仅仅是由于猫的体育锻炼。一般来说，由压力引起的免疫功能抑制已被报道可能会促进感染或肿瘤等疾病的发展。我们的研究表明，学习适当的应对行为，以避免情绪压力可能会抑制一些不必要的变化，免疫力的压力引起的，从而防止与压力有关的身体疾病的发生。