Skeletal muscle deoxygenation during exercise in diabetics Medecine

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1.Impaired red cell oxygen transport during exercise in diabeticsWe demonstrated glycosylated hemoglobin, known to have an increased affinity for oxygen, was inversely related to exercise capacity. The increase in P50(oxygen tension at which blood is 50% saturated with oxygen), promoting oxyhemoglobin dissociation, was reduced in patients compared with that in healthy subjects during exercise, which should contribute to exercise intolerance in diabetics.2.Facilitating oxyhemoglobin dissociation by exercise lactic acidosis does not occur in elevated glycosylated hemoglobin.Lactate increase during exercise is known to facilitate oxyhemoglobin dissociation. At matched submaximal work rates, lactate increase was greater in diabetic patients than in healthy subjects. The slope of the increase in P50 relative to lactate increase for diabetics was significantly reduced compared that for healthy groups. Facilitating oxyhemoglobin dissociation by lactate increase during exercise does not occur in elevated glycosylated hemoglobin, which could reduce exercise capacity in diabetics.3.Skeletal muscle deoxygenation during exercise in diabetics demonstrated with near-infrared spectroscopyChanges in tissue oxygenation of vastus lateralis muscle were measured by near-infrared spectroscopy in diabetics and healthy subjects. Oxygen availability and tissue oxygenation were significantly less in the patients than in the normal subjects. The elevated level of glycosylated hemoglobin could cause skeletal muscle deoxygenation during exercise.