Efficient organelle transformation

高效的细胞器转化

• 批准号: LP0455647
• 负责人: Prof Robert Birch
• 金额: $ 27.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-31 至 2008-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0455647
• 关键词: Efficient; organelle; transformation

Chloroplasts and mitochondria are the powerhouses of plant and animal cells. Ability to express introduced genes in these organelles has enormous biotechnological potential in agriculture and medicine, but practical development has been almost stalled for 15 years by very low transformation efficiency. Plastid transformation is today routine only in tobacco; and mitochondrial transformation has been achieved only in yeasts and algae. We have developed a solution, and achieved the key technical requirements for proof of concept. This collaboration between industry, government and university partners will deliver key Australian-owned IP, for environmentally-friendly plant biofactories, and for treatment of mitochondrial genetic disorders.

叶绿体和线粒体是植物和动物细胞的发电站。在这些细胞器中表达导入基因的能力在农业和医学中具有巨大的生物技术潜力，但由于转化效率非常低，实际开发几乎停滞了15年。质体转化目前仅在烟草中是常规的;线粒体转化仅在酵母和藻类中实现。我们已经开发出一种解决方案，并实现了概念验证的关键技术要求。工业界、政府和大学合作伙伴之间的这种合作将为环保植物生物工厂和线粒体遗传疾病的治疗提供关键的澳大利亚拥有的知识产权。