Left Ventricular Reduction Cardiomyoplasty

左心室缩小心肌成形术

• 批准号: 09671368
• 负责人: WATANABE Go
• 金额: $ 1.98万
• 依托单位: Toyama Medical and Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671368/
• 关键词: Cardiomyopasty; LV volume reduction surgery; 広背筋移植

Background. Several experimental studies on LV reduction cardiomyoplasty using the bilateral latissimus dorsi muscles were not acquired sufficient assist to the failing heart and were not estimated clearly compared with single cardiomyoplasty, In this study, a superior efficacy of our double cardiornyoplasty method was shown, compared with single cardiomyoplasty. the heart and directly sutured to each other behind the heart. Acute heart failure was induced by administering propranolol intravenously, After the hemodynamic changes with bilateral latissimus dorsi muscles assistance were measured, single cardiomyoplasty was done in the same dog. Results. By our double cardiomyoplasty, systolic aortic pressure (AoP) increased by 24 % (p<0.001), systolic pulmonary artery pressure (PAP) by 40 % (p<0.001), end-systolic elastance (Ees) by 155 % (p<0.001), and cardiac output (CO) by 55 % (p<0.001) respectively. There were clearly significant increases in AoP, PAP, Ees, SV.and CO by our double cardiomyoplasty compared with single cardiomyoplasty. Conclusion. This study demonstrated that our LV reduction cardiomyoplasty provided significant hemodynamic improvement in comparison with single cardiomyoplasty.

背景几项关于使用双侧背阔肌进行左室缩小心肌成形术的实验研究没有获得对衰竭心脏的足够辅助，并且与单次心肌成形术相比没有明确估计。在这项研究中，我们的双次心肌成形术方法与单次心肌成形术相比具有上级疗效。直接在心脏后面缝合。用心得安静脉注射诱发急性心力衰竭，测定双侧背阔肌辅助下血流动力学变化，并进行单次心肌成形术。结果双心肌成形术后主动脉收缩压（AoP）、肺动脉收缩压（PAP）、收缩末期弹性（Ees）、心输出量（CO）分别增加24%（p<0.001）、40%（p<0.001）、155%（p<0.001）。与单次心肌成形术相比，双次心肌成形术的AoP、PAP、Ees、SV和CO明显增加。结论这项研究表明，我们的左心室减少心肌成形术提供了显着的血流动力学改善相比，单一的心肌成形术。

项目成果

G Watanabe: ""New Configulation of Double Cardiomyoplasty Based on Studies of the Pressure-Volume Relationship"" PACE. 20. 1209 (1997)

G Watanabe：“基于压力-容积关系研究的双心肌成形术的新配置”PACE。

Watanabe G: "Bilateral thoracoscopic minimally invasive direct coronary artery bypass (MIDCAB) using internal thoracic arteries." Ann Thorac Surg. 65. 1673-1675 (1998)

Watanabe G：“使用胸廓内动脉的双侧胸腔镜微创直接冠状动脉搭桥术（MIDCAB）。”

Watanabe G: "Bilateral thoracoscopic minimally invasive direct coronary artery bypass (MIDCAB) using internal thoracic arteries." Ann Thorac Surg. 65. 1673-5 (1998)

Watanabe G：“使用胸廓内动脉的双侧胸腔镜微创直接冠状动脉搭桥术（MIDCAB）。”

G Watanabe: "Thoracoscopic Chemical Ablation of Aconitine induced Ventricular Tachycardia in Dogs." PACE. 20. 1578 (1997)

G Watanabe：“胸腔镜化学消融乌头碱诱发的犬室性心动过速。”