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Basic and clinical research of awake off pump CABG

清醒停泵冠状动脉搭桥术的基础与临床研究

基本信息

批准号：
16390392
负责人：
WATANABE Go
金额：
$ 7.87万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390392/
关键词：
thoracic epidural anesthesia awake off pump CABG sympathetic nerve metabolism of brain blood flow 高次脳機能術中脳血流代謝

项目摘要

Basic researchIn 2004,we evaluated the effects of thoracic epidural anesthesia (TEA) to the coronary blood flow and the augmentation of tolerance for myocardial ischemia in acute myocardial models with rats.Results of this study presented that TEA increased the coronary blood flow and decreased the area of myocardial infarction after the coronary artery occlusion.Clinical research1)We reported thoracic epidural anesthesia (TEA) inhibited the activation of sympathetic nerve strongly compared to general anesthesia and furthermore TEA reduced arrhythmia during CABG.2)We monitored the brain blood flows and the O2 saturation during off-pump CABG(OPCAB). The TEA stabilized the brain blood flow more than general anesthesia by avoiding the low blood pressure during the anastomosis.3)We reported 60 awake off pump CABG (AOCAB) by using TEA. The patients with AOCAB recovered faster than them of OPCAB with general anesthesia.4)We studied Mini-mental State Examination (MMSE) and Benton Visual Retention Test to the 20 patients with AOCAB and 20 with standard general anesthesia OPCAB. This study resulted AOCAB maintained higher level function of brain.

基础研究2004年，本实验观察了胸段硬膜外麻醉（TEA）对大鼠急性心肌缺血模型冠脉血流量的影响及对心肌缺血耐受性的增强作用。与全麻相比，TEA能明显抑制交感神经的激活，并能减少CABG术中的心律失常。2）监测非体外循环CABG（OPCAB）术中脑血流量和血氧饱和度。TEA较全麻更能稳定脑血流，避免了术中低血压的发生。3）本文报告了60例清醒非体外循环冠状动脉旁路移植术（AOCAB）。4）对20例AOCAB患者和20例标准全麻OPCAB患者进行简易精神状态检查（MMSE）和Benton视觉保持测验。结果表明AOCAB能维持较高水平的脑功能。