A study about total pulmonary replacement with artificial implantable lung.

人工植入肺全肺置换术的研究。

• 批准号: 09671382
• 负责人: SHIMIZU Nobuyoshi
• 金额: $ 1.09万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671382/
• 关键词: Artificial lung; Pulmonary replacement; Pulmonary assist; Right heart failure; Pulmonary artery banding; Canine model; Artificial device; Oxygen supply; 実験; 体内植込み; 完全置換; 肺高血圧; 体内植え込み

At present, RVAD is commonly used for a right ventricular failure (RVF). In clinic, RVF patients usually suffer poor gas exchange due to cardiac failure. The purpose of this study is whether pumpless ECMO in right ventricle (RY) to left atrium (LA) bypass could be useful as a means of a treatment for a chronic RYF.Experiment I.Ten mongrel dogs (2.5-6.0 kg, mean 3.9kg) were performed banding of the main pulmonary artery (mPA), aimed for RVF due to pulmonary hypertension. A pressure study of the right heart was performed after a long term raising (97-205 days, mean 160 days). All the cases showed the mean RY pressure (m-RVP) [mmHg]<greater than or equal>20 (average 30.2*9Experiment II.Implantation of the artificial lung (MENOX EL2000, Kuraray Co. Japan) was performed between RY outlet and LA for ten of the RVF model. As we lost one animal during operation, nine (4.8-8.4kg, mean 6.5kg) were used to evaluate the gas transfer and the cardiac function. All the cases showed the m-RVP (average 20.7+4.2 mmHg) after the RV-LA bypass was equal to the preoperative value or dropped, and the average cardiac function tended to be improved. Experiment III.After experiment II, the nine dogs were performed ligation of mPA and total RV-LA bypass was started. Five (4.8*8.4kg, mean 6.6kg) of nine RVF model were supported over 6 hours and evaluated the gas transfer and cardiac function (group 1), while the other four died soon after ligation of mPA due to RVF.Five non-PA banding mongrels with the membrane oxygenator were used as control (Group II). Group I, as well as Group II, showed good gas transfer rates, averages of 32.5*8.3m1/min. of 02 and 37.2*11.6m1/min, of CO2 with a blood flow rate of 0.68*0.19 L/min..A partial bypass between RV-LA with the commercially available membrane oxygenator provides better recovary of RVF than a total bypass in RYF model.

目前，RVAD通常用于右心室衰竭（RVF）。在临床上，裂谷热患者常因心力衰竭而导致气体交换不良。本研究的目的是探讨右心室-左心房转流无泵ECMO是否可以作为治疗慢性RYF的一种有效手段。实验一：10只杂种犬（2.5-6.0 kg，平均3.9 kg）行主肺动脉（mPA）结扎术，旨在治疗由肺动脉高压引起的RVF。长期（97-205天，平均160天）抬高后进行右心压力测定。所有病例的平均RY压力（m-RVP）[mmHg]<greater than or equal>均为20（平均30.2* 9）。实验II.在10例RVF模型的RY出口和LA之间植入人工肺（MENOX EL 2000，Kuraray Co. Japan）。由于我们在手术中损失了一只动物，因此使用了9只动物（4.8-8.4kg，平均6.5kg）来评估气体转移和心脏功能。所有病例均显示右心室-左心房转流术后m-RVP（平均20.7 ± 4.2mmHg）与术前相当或下降，平均心功能有改善趋势。实验三：实验二结束后，9只犬结扎mPA，开始全RV-LA转流。9只RVF模型中5只（4.8 × 8.4kg，平均6.6kg）在6小时内进行气体转运和心功能评价（第1组），另4只因RVF结扎mPA后即刻死亡（第2组）。第I组和第II组显示出良好的气体传输速率，O2的平均值为32.5*8.3m1/min，CO2的平均值为37.2*11.6m1/min，血液流速为0.68*0.19 L/min。RV-LA与市售膜式氧合器之间的部分旁路比RYF模型中的完全旁路提供更好的RVF复律。

项目成果

為季清和: "MENOX^<TM>EL2000による人工肺植え込みの実験的検討" 膜型肺. 21号. (1998)

Kiyokazu Tametsuki：“使用 MENOX^<TM>EL2000 进行人工肺植入的实验研究”，膜肺，第 21 期。

為季清和 外: "MENOXTMEL2000による人工肺植込みの実験的検討" Membrene Artificial Lung. 21. 56-60 (1998)

Kiyokazu Tametsuki 等：“使用 MENOXTMEL2000 进行人工肺植入的实验研究”Membrene Artificial Lung。 21. 56-60 (1998)

Tamesue K., Ichiba S., Aoe M., Kawai T., Yamamoto H., Nawa S., Shimizu N., Tanaka S.: "An experimental study about implantation of artificial lung with MENOX EL 2000" Membrene Artificial Lung. 21. 56-60 (1998)

Tamesue K.、Ichiba S.、Aoe M.、Kawai T.、Yamamoto H.、Nawa S.、Shimizu N.、Tanaka S.：“关于使用 MENOX EL 2000”膜人工肺植入人工肺的实验研究。