Effect of Interferon-α treatment for HCV-positive renal transplant recipients and hempdialysed patients.

(Aim方法：对HCV阳性的血液透析和移植患者，用天然型干扰素α（INFα）治疗，每次500×10^4U，连用14天，以后每周3次，每次500×10^6U，连用6个月。肾移植受者用INFα1000×10^6U，连用14天，然后用INF α 1000×10^6U，每周3次，连用6个月。结果12例血液透析患者和10例肾移植受者入选本研究。所有22名患者均表现出至少部分缓解，转氨酶正常化且HCV-RNA呈阴性。11名患者在INFα治疗结束6个月后表现出完全缓解，但HCV-RNA未恢复阳性。结论INFα治疗对HCV感染的血液透析患者和肾移植受者有较好的抗HCV效果。

(Aim ＆ method)Natural typer interferon α(INFα)was administered to HCV positive hemodialysis and transplant patients in order to eliminate HCV.Hemodialysed patients were received INFα500×10^4U for 14 days and followed by 500×10^6U, 3 times/week, for 6 months. Renal transplant recipients with HCV were administered INFα1000×10^6U for 14days and followed by 1000×10^6U, 3 times/week for 6 months.(Results)12 hemodialysed patients an 10 renal transplant recipients were enrolled in this study. All 22 patients showed at least partial response with normalization of transaminase and negative HCV-RNA.11 patients showed complete response without returning HCV-RNA positive after 6 months of conclusion of INFαtreatment.(Conclusion)INFαtreatment for the hemodialyzed patients and renal transplant recipients with HCV was highly effective to eliminate HCV.