Effect of Interferon-α treatment for HCV-positive renal transplant recipients and hempdialysed patients.

干扰素-α 治疗对 HCV 阳性肾移植受者和血液透析患者的影响。

• 批准号: 09671652
• 负责人: TANABE Kazunari
• 金额: $ 1.79万
• 依托单位: Department of Urology, Kidney Center, Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671652/
• 关键词: HCV; renal transplantation; Interferon-α; C型肝炎; 慢性腎不全; インターフェロン

(Aim ＆ method)Natural typer interferon α(INFα)was administered to HCV positive hemodialysis and transplant patients in order to eliminate HCV.Hemodialysed patients were received INFα500×10^4U for 14 days and followed by 500×10^6U, 3 times/week, for 6 months. Renal transplant recipients with HCV were administered INFα1000×10^6U for 14days and followed by 1000×10^6U, 3 times/week for 6 months.(Results)12 hemodialysed patients an 10 renal transplant recipients were enrolled in this study. All 22 patients showed at least partial response with normalization of transaminase and negative HCV-RNA.11 patients showed complete response without returning HCV-RNA positive after 6 months of conclusion of INFαtreatment.(Conclusion)INFαtreatment for the hemodialyzed patients and renal transplant recipients with HCV was highly effective to eliminate HCV.

（目的与方法）采用自然型干扰素α(INFα)治疗HCV阳性血液透析和移植患者，以消除HCV。血液透析患者接受INFα500×10^4U治疗14天，随后接受500×10^6U治疗，每周3次，连续6个月。HCV肾移植受者给予INFα1000×10^6U治疗14天，随后给予1000×10^6U治疗，每周3次，持续6个月。（结果）12例血液透析患者和10例肾移植受者纳入本研究。所有22例患者均表现出转氨酶正常化和HCV-RNA阴性至少部分缓解。11例患者在治疗结束6个月后完全缓解，未出现HCV-RNA阳性。（结论）血液透析患者和肾移植受者的丙型肝炎病毒（HCV）治疗中使用inf α能有效消除HCV。

项目成果

H.Toma: "Pregnacy in women receiving renal dialysis or transplantation in Japan : a nation wide survey."Nephrol Dial Transplantation. 14. 1511-1516 (1999)

H.Toma：“日本接受肾透析或肾移植的女性怀孕情况：一项全国范围的调查。”肾拨号移植。

徳本直彦ら: "移植腎長期生着-合併症とその対策-肝障害"腎と透析. 47. 511-518 (1999)

Naohiko Tokumoto 等人：“移植肾脏的长期存活 - 并发症及其对策 - 肝损伤”《肾脏与透析》47. 511-518 (1999)。

Tanabe: "Long-tem renal-function after pregrany in reul translait" Transplant Proc. 29. 1567-1568 (1997)

田边：“reul translait 中妊娠后的长期肾功能”移植过程。

Tanabe: "Retroviral transduction of intercellula adhesion molecule-1 enhances endo thelial attachment of blulda cencc" Wol Res. 25. 401-405 (1997)

Tanabe：“细胞间粘附分子-1 的逆转录病毒转导增强了 blulda cencc 的内皮附着”Wol Res。

K.Tanabe: "Long-Term Results in Mizoribine-Treated Renal Transplant Recipients : A Prospective, Randomized Trial of Mizoribine and Azathioprine Under Cyclosporine-Based Immunosuppression"Transplant Proc.. 31. 2877-2879 (1999)

K.Tanabe：“Mizoribine 治疗的肾移植受者的长期结果：基于环孢菌素的免疫抑制下 Mizoribine 和硫唑嘌呤的前瞻性随机试验”Transplant Proc. 31. 2877-2879 (1999)