Effect of Interferon-α treatment for HCV-positive renal transplant recipients and hempdialysed patients.

（目的与方法）采用自然型干扰素α(INFα)治疗HCV阳性血液透析和移植患者，以消除HCV。血液透析患者接受INFα500×10^4U治疗14天，随后接受500×10^6U治疗，每周3次，连续6个月。HCV肾移植受者给予INFα1000×10^6U治疗14天，随后给予1000×10^6U治疗，每周3次，持续6个月。（结果）12例血液透析患者和10例肾移植受者纳入本研究。所有22例患者均表现出转氨酶正常化和HCV-RNA阴性至少部分缓解。11例患者在治疗结束6个月后完全缓解，未出现HCV-RNA阳性。（结论）血液透析患者和肾移植受者的丙型肝炎病毒（HCV）治疗中使用inf α能有效消除HCV。

(Aim ＆ method)Natural typer interferon α(INFα)was administered to HCV positive hemodialysis and transplant patients in order to eliminate HCV.Hemodialysed patients were received INFα500×10^4U for 14 days and followed by 500×10^6U, 3 times/week, for 6 months. Renal transplant recipients with HCV were administered INFα1000×10^6U for 14days and followed by 1000×10^6U, 3 times/week for 6 months.(Results)12 hemodialysed patients an 10 renal transplant recipients were enrolled in this study. All 22 patients showed at least partial response with normalization of transaminase and negative HCV-RNA.11 patients showed complete response without returning HCV-RNA positive after 6 months of conclusion of INFαtreatment.(Conclusion)INFαtreatment for the hemodialyzed patients and renal transplant recipients with HCV was highly effective to eliminate HCV.