Effect of Interferon-α treatment for HCV-positive renal transplant recipients and hempdialysed patients.

目的与方法对丙型肝炎病毒阳性的血液透析和移植患者应用自然型干扰素α(INFα)清除丙型肝炎病毒，透析后给予α5 0 0×10 4U，14d后再给予5 0 0×10 6U，每周3次，疗程6个月。结果12例肾移植患者和10例肾移植受者均接受α治疗，每次1000×106U，每周3次，疗程6个月。22例丙型肝炎转氨酶正常、丙型肝炎病毒α阴性的患者均有部分缓解，11例患者治疗6个月后完全缓解，无丙型肝炎病毒阳性。(结论对血液透析患者和肾移植术后丙型肝炎病毒感染者，应用干扰素α治疗能有效地消除丙型肝炎病毒。

(Aim ＆ method)Natural typer interferon α(INFα)was administered to HCV positive hemodialysis and transplant patients in order to eliminate HCV.Hemodialysed patients were received INFα500×10^4U for 14 days and followed by 500×10^6U, 3 times/week, for 6 months. Renal transplant recipients with HCV were administered INFα1000×10^6U for 14days and followed by 1000×10^6U, 3 times/week for 6 months.(Results)12 hemodialysed patients an 10 renal transplant recipients were enrolled in this study. All 22 patients showed at least partial response with normalization of transaminase and negative HCV-RNA.11 patients showed complete response without returning HCV-RNA positive after 6 months of conclusion of INFαtreatment.(Conclusion)INFαtreatment for the hemodialyzed patients and renal transplant recipients with HCV was highly effective to eliminate HCV.