Study on alternation preparations for intravenous infusion system

静脉输液系统交替制剂的研究

• 批准号: 09672286
• 负责人: SUGIBAYASHI Kenji
• 金额: $ 1.73万
• 依托单位: Josai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672286/
• 关键词: intravenous infusion; jet injector; iontophoresis; electroporation; transdermal absorption; liquid injector; powder injector

Two methodologies for creating amd enlarging skin permeation Ionic of drug were examined, and the combined effect with iontophoresis (IP) was evaluated.Skin permeation rate of diclofenac and angiotensin II as model drugs increased, by treatments with jet injector (JI) and constant voltage IP. In the combined use of JI and constant voltage IP, the permeation rate of drug was higher than these single uses. This combined effect is due to lowered skin resistance by JI. Controlling of skin permeation of drugs, however, was difficult during the constant voltage lP. JP and short term constant voltage IP followed by constant current IP may be the optimum way for the enhanced skin delivery of drug. Low voltage electroporation (EP) alone did not change the skin permeation of benzoic acid as a model drug, but improved the permeation by combined with IP.In conclusion, further improvement of the skin permeability of drugs was achieved by treatment JI and/or EP to make pores in stratum corneum followed by IP. These meanes probably are useful for the development of new skin delivery systems of drugs including peptide and DNA.

本文研究了两种药物离子经皮渗透的方法，并与离子导入法（IP）联合应用，以双氯芬酸和血管紧张素II为模型药物，采用喷射注射器（JI）和恒压IP处理，均能增加药物的经皮渗透速率。JI与恒压IP联合使用时，药物的渗透速率高于单独使用。这种组合效应是由于JI降低了皮肤电阻。然而，在恒定电压IP期间，难以控制药物的皮肤渗透。JP和短期恒压IP后恒流IP可能是增强药物经皮给药的最佳方式。单独使用低电压电穿孔（EP）并不改变苯甲酸作为模型药物的皮肤渗透性，但与IP联合使用可提高药物的皮肤渗透性。总之，通过处理JI和/或EP使角质层形成孔隙，然后IP，可进一步提高药物的皮肤渗透性。这些方法可能有助于开发新的肽类和DNA类药物的皮肤给药系统。

项目成果

M.Yoshida et al.: "Skin permeation enhancing effect of drug by electroporation. The analysis using the lines of electric force"Xenobio. Metahol. And Dispos.. 14. S190 (1999)

M.Yoshida 等人：“通过电穿孔增强药物的皮肤渗透作用。使用电力线进行分析”Xenobio。

渡辺哲也 ら: "薬物の経皮吸収促進効果に対するElectroporationの適用電圧と電極の位置の影響"Drug Delivery System. 13. 300 (1998)

Tetsuya Watanabe 等人：“电穿孔中施加的电压和电极位置对促进药物透皮吸收的影响”药物输送系统。

吉田牧 ら: "Electroporationによる薬物の皮膚透過促進効果〜電気力線を用いた解析〜"薬物動態. 14. S190 (1999)

Maki Yoshida 等人：“电穿孔促进药物的皮肤渗透作用 - 使用电力线进行分析 -”药代动力学 14. S190 (1999)。

鍵野みどり ら: "ジクロフェナクの皮膚透過に及ぼすジェットインジェクターとイオンフォレーシスの併用効果とその解析"薬物動態. 12. S285 (1997)

Midori Kagino 等人：“喷射注射器和离子电渗疗法的联合使用对双氯芬酸皮肤渗透性的影响及其分析” Pharmacokinetics 12. S285 (1997)。

吉田牧: "Electroporationによる薬物の皮膚透過促進効果 〜電気力線を用いた解析〜"薬物動態学. 14. S190 (1999)

吉田真希：“通过电穿孔促进药物的皮肤渗透作用〜使用电力线进行分析〜”药代动力学14.S190（1999）。