Study on alternation preparations for intravenous infusion system

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Two methodologies for creating amd enlarging skin permeation Ionic of drug were examined, and the combined effect with iontophoresis (IP) was evaluated.Skin permeation rate of diclofenac and angiotensin II as model drugs increased, by treatments with jet injector (JI) and constant voltage IP. In the combined use of JI and constant voltage IP, the permeation rate of drug was higher than these single uses. This combined effect is due to lowered skin resistance by JI. Controlling of skin permeation of drugs, however, was difficult during the constant voltage lP. JP and short term constant voltage IP followed by constant current IP may be the optimum way for the enhanced skin delivery of drug. Low voltage electroporation (EP) alone did not change the skin permeation of benzoic acid as a model drug, but improved the permeation by combined with IP.In conclusion, further improvement of the skin permeability of drugs was achieved by treatment JI and/or EP to make pores in stratum corneum followed by IP. These meanes probably are useful for the development of new skin delivery systems of drugs including peptide and DNA.