Development of Synthetic Reactions and Effect Chemicals

合成反应和效应化学品的发展

• 批准号: 10045029
• 负责人: WADA Makoto
• 金额: $ 1.47万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10045029/
• 关键词: Allylation; Allyltin; Allylbismuth; Aqueous media; Water; Lignan; Cyclopeptide; Green Chemistry; 環境調和; 有機合成; 高分子担持触媒; 還元反応; 工業的プロセス; ストロンチウム; アルキル化反応; カルボニル化合物; ペプチド; 抗血栓作用; グリーン科学; ビスマス化合物; スズ化合物; アリル化反応; 含水溶媒中; リグナン類

This summary presents the research results of development of synthetic reactions and effect chemicals.1) Allylation of aldehydes by using allylic halides prepared in situ from allylic alcohols in the presence of metallic bismuth.2) Allylation of aldehydes by using allyltin compounds and allylbismuth compounds in aqueous media or water.3) Solvent-mediated chemoselective reduction of aldehydes by using tributyltin hydride in methanol, aqueous organic solvents, or water : an environmentally benign process.4) Preparation and use of sterically hindered organobis (2,4,6-triisopropylphenyl) hydro-borates and their polystyrene derivatives for the diastereoselective reduction of ketones.5) Synthesis of Lignans using Ruthenium Tetra (trifluoroacetate) and PIFA.6) Synthesis and Application of Cyclopeptides and Cyclodepsipeptides.

1)在金属铋存在下烯丙基醇原位合成的烯丙基卤化物催化醛的烯丙基化反应。2)在水介质或水中使用烯丙基锡化合物和烯丙基铋化合物进行醛的烯丙基化反应。3)在甲醇、有机溶剂或水中，溶剂介导的三丁基锡氢化物化学选择性还原醛：一种环境友好的过程。4)制备和使用空间受阻的有机二氮化合物(2，4，用于酮的非对映选择性还原的(6-三异丙基苯基)氢硼酸酯及其聚苯乙烯衍生物。5)用四(三氟乙酸酯)和PIFA合成木脂素。6)环肽和环肽的合成和应用。

项目成果

N.Miyoshi, M.Nishio, S.Murakami, T.Fukuma, and M.Wada: "A Convenient One Pot Allylation of Aldehydes with Allylic Halides Prepared in situ from Allylic Alcohols in the Presence of Metallic Bismuth"Bull.Chem.Soc.Jpn.. 73. 689-692 (2000)

N.Miyoshi、M.Nishio、S.Murakami、T.Fukuma 和 M.Wada：“在金属铋存在下，醛与烯丙醇原位制备的烯丙卤化物的便捷一锅烯丙基化”Bull.Chem.Soc

N.Miyoshi: "A Convenient One Pot Allylation of Aldehydes with Allylic Halides Prepared in situ from Allylic Alcohols in the Presence of Metallic Bismuth,"Bull.Chem.Soc.Jpn.. 73. 689-692 (2000)

N.Miyoshi：“在金属铋存在下，醛与烯丙醇卤化物的便捷一锅烯丙基化，由烯丙醇原位制备”，Bull.Chem.Soc.Jpn.. 73. 689-692 (2000)

J.S.Davies: "Synthesis and Properties of Gla- and Phe containing analogues of cyclic RGD pentapeptides,"J.Chem.Soc.Perkin Trans.1. 2907-2915 (2000)

J.S.Davies：“含有 Gla- 和 Phe 的环状 RGD 五肽类似物的合成和性质”，J.Chem.Soc.Perkin Trans.1。

R.S.Ward: "Lignans,Neolignans and Related Compounds,"Natural Product Reports. 16. 75-96 (1999)

R.S.Ward：“木脂素、新木脂素和相关化合物”，天然产品报告。

M.Wada: "Organic Synthesis by Using Bismuth and Tin Compounds : Synthetic Organic Reactions in Aqeous Media or Water,"J.Syn.Org.Chem.Jpn.. 57. 689-697 (1999)

M.Wada：“使用铋和锡化合物的有机合成：水介质或水中的有机合成反应”，J.Syn.Org.Chem.Jpn.. 57. 689-697 (1999)