Sulf2-remodeling of heparan sulfate present in brain amyloids

脑淀粉样蛋白中硫酸乙酰肝素的 Sulf2 重塑

• 批准号: 15K08265
• 负责人: UCHIMURA Kenji
• 金额: $ 3.08万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08265/
• 关键词: 糖鎖; 酵素; 生体分子; 脳神経疾患

项目成果

Gene disruption of GlcNAc 6-O-sulfotransferase-1 results in loss of microglial keratan sulfate and alleviation of Alzheimer's pathogenesis in mice

GlcNAc 6-O-sulfotransferase-1 基因破坏导致小胶质细胞硫酸角质素丢失并减轻小鼠阿尔茨海默病发病机制

• 发表时间: 2015
• 作者: Zui Zhang;Yoshiko Uchimura;Tahmina Foyez;Shiori Niimi;Hitomi Hoshino;Tomomi Hosono;Makoto Michikawa;Kenji Kadomatsu and Kenji Uchimura
• 通讯作者: Kenji Kadomatsu and Kenji Uchimura

Enzymatic remodeling of heparan sulfate: a therapeutic strategy for systemic and localized amyloidoses?

• DOI: 10.4103/1673-5374.179043
• 发表时间: 2016-03
• 期刊: Neural regeneration research
• 影响因子: 6.1
• 作者: Nishitsuji K;Saito H;Uchimura K
• 通讯作者: Uchimura K

Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.

焓驱动的与硫酸化糖胺聚糖的相互作用促进精氨酸肽的细胞膜渗透。

• DOI: 10.1016/j.bbamem.2016.03.021
• 发表时间: 2016
• 期刊: Biochimica et Biophysica Acta
• 作者: Takechi-Haraya Y;Nadai R;Kimura H;Nishitsuji K;Uchimura K;Sakai-Kato K;Ka-wakami K;Shigenaga A;Kawakami T;Otaka A;Hojo H;Sakashita N;Saito H
• 通讯作者: Saito H